Cyclization and oxidation of o-bromophenylacetamides for the synthesis of oxindoles and isoindigoes
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DOI: 10.1016/j.tet.2017.12.005
Abstract: Abstract N-substituted oxindoles were obtained through a facile KOH/DMSO promoted intramolecular cyclization of o-bromophenylacetamides in good yields. Furthermore, isoindigo derivatives were readily synthesized through sequential intramolecular cyclization, oxidation and condensation of o-bromophenylacetamide in the presence… read more here.
Keywords: oxidation bromophenylacetamides; bromophenylacetamides synthesis; cyclization; cyclization oxidation ... See more keywords
A novel cyclization/oxidation strategy for a two-step synthesis of (Z)-aurone
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DOI: 10.1016/j.tetlet.2017.02.074
Abstract: An efficient and facile two-step strategy for the synthesis of (Z)-aurone from arylacetylenes and salicyladehydes, via silver(I) nitrate mediated cyclization/oxidation in the presence of potassium carbonate has been developed. The key feature of our method… read more here.
Keywords: strategy; synthesis aurone; two step; cyclization oxidation ... See more keywords
One-Pot Acid-Catalyzed Ring-Opening/Cyclization/Oxidation of Aziridines with N-Tosylhydrazones: Access to 1,2,4-Triazines.
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DOI: 10.1021/acs.orglett.7b00101
Abstract: A new, three-step, telescoped reaction sequence for the regioselective conversion of N-tosyl hydrazones and aziridines to 3,6-disubstituted and 3,5,6-trisubstituted 1,2,4-triazines is described. The process involves an efficient nucleophilic ring opening of the aziridine, giving access… read more here.
Keywords: ring opening; one pot; opening cyclization; cyclization oxidation ... See more keywords