Copper(ii)-catalyzed tandem cyclization for the synthesis of benzo[d][1,3]thiazin-2-yl phosphonates involving C–P and C–S bond formation
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DOI: 10.1039/d0ra06671k
Abstract: A copper(II)-catalyzed, high-efficiency and atom-economical synthesis of valuable organophosphorus compounds via tandem cyclization of o-alkynylphenyl isothiocyanates with phosphites is described. This protocol, having a good functional-group compatibility, provides a simple and direct pathway to organophosphorus… read more here.
Keywords: tandem cyclization; cyclization; catalyzed tandem; cyclization synthesis ... See more keywords
Organocatalytic enantioselective (4+3) cyclization for the synthesis of spiro-fused heterocyclic compounds containing isoindolinone, oxepine and indole moieties.
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DOI: 10.1039/d4cc03230f
Abstract: A refined strategy has been developed to control the regioselective asymmetric (4+3) cyclization of α-(3-isoindolinonyl) propargylic alcohols with 2-indolylmethanols, utilizing chiral phosphoric acid catalysis. This innovative organocatalytic cyclization yields spiro isoindolinone-oxepine-fused indoles featuring a spiro-quaternary… read more here.
Keywords: cyclization synthesis; enantioselective cyclization; cyclization; organocatalytic enantioselective ... See more keywords
Electrochemically Driven Tandem Addition–Cyclization: Synthesis of Thiadiazinanes and Thiophosphonates
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DOI: 10.1039/d5gc01831e
Abstract: We herein report a robust electrochemical one-pot two-step strategy for the efficient synthesis of valuable 1,2,5-thiadiazinane and thiophosphonate derivatives. The methodology employs electricity as a clean oxidant and catalytic tetrabutylammonium... read more here.
Keywords: cyclization synthesis; electrochemically driven; addition cyclization; synthesis ... See more keywords
1,5-Hydride-Shift-Triggered Cyclization for the Synthesis of Unsymmetric Julolidines
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DOI: 10.1055/a-1559-2728
Abstract: Directly accessible 8-substituted tetrahydroquinolines undergo 1,5-hydride-shift-triggered cyclization to provide difficult to access julolidine derivatives in yields of 21–98% under scandium(III) triflate catalysis. Additionally, the scope of the reaction, several follow-up transformations and a remarkable side… read more here.
Keywords: shift triggered; hydride shift; triggered cyclization; synthesis unsymmetric ... See more keywords