Articles with "cyclization trifluoromethylation" as a keyword



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Copper-Mediated Domino Cyclization/Trifluoromethylation/Deprotection with TMSCF3: Synthesis of 4-(Trifluoromethyl)pyrazoles.

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Published in 2017 at "Organic letters"

DOI: 10.1021/acs.orglett.6b03822

Abstract: A copper-mediated synthesis of 4-(trifluoromethyl)pyrazoles is described. In one step from readily accessible α,β-alkynic tosylhydrazones, a remarkable domino sequence of cyclization, trifluoromethylation, and detosylation takes place to furnish the 4-CF3 N-H pyrazole cores with good… read more here.

Keywords: copper mediated; cyclization trifluoromethylation; trifluoromethyl pyrazoles; synthesis trifluoromethyl ... See more keywords