Unexpected intramolecular nucleophilic cyclization of ureidoacetamide: A novel route towards the synthesis of 2,4,5-trisubsituted oxazoles
Sign Up to like & getrecommendations! Published in 2019 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2019.05.028
Abstract: Abstract A variety of N, 2-diaryl-2-ureidoacetamide prepared from the condensation of N-aryl-α-aminoamide with potassium cyanate (KOCN) undergo efficient Hendrickson’s reagent-mediated nucleophilic cyclization to afford 2,5-diamine-4-aryloxazoles. The two-step synthesis provides seven target products in yields of… read more here.
Keywords: synthesis; nucleophilic cyclization; unexpected intramolecular; cyclization ... See more keywords