A 6-endo-dig Thiolative Cyclization of Yne-Ynamides: Access to Thiodihydropyridin-2-ones.
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DOI: 10.1021/acs.orglett.2c03225
Abstract: A straightforward regioselective intramolecular 6-endo-dig cyclization of yne-tethered ynamide is herein developed. The reaction involves an intramolecular enolate attack of ketene-N,O-acetals, generated in situ from yne-ynamide and methanesulfonic acid, to the alkyne moiety activated by… read more here.
Keywords: dig thiolative; cyclization yne; access; endo dig ... See more keywords