2,5-Diketopiperazines: A New Class of Poly(ADP-ribose)polymerase Inhibitors
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DOI: 10.1134/s0006297918020074
Abstract: We show for the first time that natural 2,5-diketopiperazines (cyclic dipeptides) can suppress the activity of the important anticancer target poly(ADP-ribose)polymerase (PARP). Cyclo(L-Ala-L-Ala) and cyclo(L-Ala-D-Ala) can interact with the key residues of the PARP-1 active… read more here.
Keywords: ala ala; ala; poly adp; ribose polymerase ... See more keywords