“Metal –free” synthesis of 1,2,3-triazoles via tandem azidation, intramolecular [3+2]-cycloaddition and aromatization of ethyl acrylate derivatives
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DOI: 10.1016/j.tetlet.2018.05.020
Abstract: Abstract An efficient “one-pot” method for the synthesis of substituted 1,2,3-triazole derivatives in excellent yields as single regioisomer is reported. The key transformation involves an atom-efficient tandem azidation, intramolecular [3+2]-cycloaddition and aromatization of acrylate derivatives… read more here.
Keywords: azidation intramolecular; tandem azidation; cycloaddition aromatization; acrylate derivatives ... See more keywords
Metal-Free [5 + 1] Cycloaddition-Aromatization of Benzotriazoles and Sulfur Ylides to Construct 1,2,4-Benzotriazines.
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DOI: 10.1021/acs.orglett.2c02064
Abstract: Reported herein is a novel [5 + 1] cycloaddition-aromatization of benzotriazoles and sulfur ylides to efficiently construct 1,2,4-benzotriazine derivates with good yield. This new protocol does not employ any transition metal reagent and enables the… read more here.
Keywords: aromatization benzotriazoles; metal free; benzotriazoles sulfur; sulfur ylides ... See more keywords