Catalytic Asymmetric Desymmetrizing [4+2] Cycloaddition/Base-Mediated Oxidative Aromatization Sequence: De Novo Synthesis of Isobenzofuranone-Embedded Chiral Arenes.
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DOI: 10.1021/acs.orglett.4c04342
Abstract: Herein, an organocatalytic asymmetric desymmetrizing [4+2] cycloaddition/base-mediated oxidative aromatization reaction sequence has been developed between spirophthalide 2,5-cyclohexadienones and β-methyl cinnamaldehydes. The reaction proceeds through in situ chiral dienamine intermediate formation, and the densely functionalized spirocyclic… read more here.
Keywords: base mediated; mediated oxidative; cycloaddition base; asymmetric desymmetrizing ... See more keywords