Palladium-Catalyzed [2+3] Cycloaddition/Cross-Coupling Reaction: Z/E and Diastereoselective Synthesis of Dendralene-Functionalized Dihydrofurans.
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DOI: 10.1021/acs.orglett.2c01605
Abstract: Herein, we describe a Pd-catalyzed [2+3] cycloaddition/cross-coupling reaction of allenyl acetates for the Z/E selective and diastereoselective synthesis of dendralene-functionalized dihydrofurans. Remarkably, mechanistic studies show the formation of an epoxide from a carbonyl bond via… read more here.
Keywords: diastereoselective synthesis; catalyzed cycloaddition; cross coupling; coupling reaction ... See more keywords