Steric- and Electronic-Controlled Intramolecular [2 + 2]-Cycloaddition of Cyclohexadienone-Containing 1,7-Enynes.
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DOI: 10.1021/acs.orglett.1c04232
Abstract: Herein we have developed the silver-catalyzed electronic- and steric-controlled intramolecular formal [2 + 2]-cycloaddition of alkyne-tethered cyclohexadienones. Substrates with electron-rich alkynes and a less hindered quaternary carbon center afford tricyclic fused cyclobutenes through 1,7-enyne cyclization.… read more here.
Keywords: controlled intramolecular; electronic controlled; intramolecular cycloaddition; steric electronic ... See more keywords