Copper(I)-Catalyzed 1,3-Dipolar Cycloaddition of Ketonitrones to Dialkylcyanamides: A Step toward Sustainable Generation of 2,3-Dihydro-1,2,4-oxadiazoles
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DOI: 10.1021/acsomega.7b00130
Abstract: CuI-catalyzed cycloaddition (CA) of the ketonitrones, Ph2C=N+(R′)O– (R′ = Me, CH2Ph), to the disubstituted cyanamides, NCNR2 (R = Me2, Et2, (CH2)4, (CH2)5, (CH2)4O, C9H10, (CH2Ph)2, Ph(Me)), gives the corresponding 5-amino-substituted 2,3-dihydro-1,2,4-oxadiazoles (15 examples) in good… read more here.
Keywords: dihydro oxadiazoles; cycloaddition ketonitrones; catalyzed dipolar; dipolar cycloaddition ... See more keywords