Regioselective Synthesis of 5-Trifluoromethyl 1,2,4-Triazoles via [3 + 2]-Cycloaddition of Nitrile Imines with CF3CN
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DOI: 10.3390/molecules27196568
Abstract: We herein describe a general approach to 5-trifluoromethyl 1,2,4-triazoles via the [3 + 2]-cycloaddition of nitrile imines generated in situ from hydrazonyl chloride with CF3CN, utilizing 2,2,2-trifluoroacetaldehyde O-(aryl)oxime as the precursor of trifluoroacetonitrile. Various functional… read more here.
Keywords: triazoles via; via cycloaddition; trifluoromethyl triazoles; cycloaddition nitrile ... See more keywords
Facile synthesis of hydantoin/1,2,4-oxadiazoline spiro-compounds via 1,3-dipolar cycloaddition of nitrile oxides to 5-iminohydantoins
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DOI: 10.3762/bjoc.21.118
Abstract: The cycloaddition of 1,3-dipoles at C=N bonds is a relatively rare process, in contrast to the widespread cycloaddition reactions at C=C, C≡C, and C=S bonds. In this study, we present the syntheses of novel hydantoin/1,2,4-oxadiazoline… read more here.
Keywords: dipolar cycloaddition; oxadiazoline spiro; cycloaddition nitrile; hydantoin oxadiazoline ... See more keywords