Catalytic Asymmetric Dearomative 1,3-Dipolar Cycloaddition of 2-Nitrobenzothiophenes and Isatin-Derived Azomethine Ylides.
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DOI: 10.1021/acs.orglett.1c03318
Abstract: An enantioselective dearomative 1,3-dipolar cycloaddition of 2-nitrobenzothiophenes and isatin-derived azomethine ylides with a bifunctional hydrogen-bonding thiourea catalyst was established, giving polyheterocyclic compounds in excellent results (up to 99% yield, >20:1 dr for all cases and… read more here.
Keywords: dearomative dipolar; cycloaddition nitrobenzothiophenes; derived azomethine; dipolar cycloaddition ... See more keywords