Gold-Catalyzed Regio- and Diastereoselective [3 + 2] Cycloaddition/Unactivated C(sp3)-H Bond Insertion of o-1,6-Enynyl Benzaldehydes to Oxa-Bridged Polycycles.
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DOI: 10.1021/acs.orglett.5c00891
Abstract: An efficient and expeditious method to assemble oxa-bridged polycycles bearing up to six contiguous stereocenters from a gold(I)-catalyzed [3 + 2] cycloaddition/unactivated C(sp3)-H bond insertion cascade of o-1,6-enynyl benzaldehydes at a low catalyst loading of… read more here.
Keywords: cycloaddition unactivated; gold catalyzed; bridged polycycles; unactivated sp3 ... See more keywords
Ruthenium-Catalyzed Intermolecular [2 + 2] Cycloaddition of Unactivated Allenes and Alkynes with Unusual Regioselectivity
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DOI: 10.1021/jacs.5c11285
Abstract: Described here is an efficient protocol for intermolecular [2 + 2] cycloaddition of unactivated and unsymmetrical allenes and alkynes with unusual regioselectivity, counterintuitively favoring the most hindered isomer. CpRu(MeCN)3PF6 served as a uniquely effective catalyst,… read more here.
Keywords: regioselectivity; intermolecular cycloaddition; cycloaddition unactivated; unusual regioselectivity ... See more keywords