Puckering the Planar Landscape of Fragments: Design and Synthesis of a 3D Cyclobutane Fragment Library
Sign Up to like & getrecommendations! Published in 2022 at "Chemmedchem"
DOI: 10.1002/cmdc.202200113
Abstract: Fragment‐based drug discovery (FBDD) has a growing need for unique screening libraries. The cyclobutane moiety was identified as an underrepresented yet attractive three‐dimensional (3D) scaffold. Synthetic strategies were developed via a key 3‐azido‐cyclobutanone intermediate, giving… read more here.
Keywords: fragments design; landscape fragments; fragment; cyclobutane ... See more keywords
The relevance of the relative configuration in the folding of hybrid peptides containing β-cyclobutane amino acids and γ-amino-l-proline residues
Sign Up to like & getrecommendations! Published in 2017 at "Tetrahedron"
DOI: 10.1016/j.tet.2017.09.011
Abstract: Abstract Four new series of diastereomeric β,γ-di- and β,γ-tetrapeptides derived from conveniently protected (1 R ,2 S )- and (1 S ,2S)-2-aminocyclobutane-1-carboxylic acid and cis - and trans -γ-amino- l -proline joined in alternation have… read more here.
Keywords: relative configuration; amino proline; cyclobutane amino; peptides containing ... See more keywords
Supramolecular Construction of an Aldehyde-Cyclobutane via the Solid State: Combining Reversible Imine Formation and Metal-Organic Self-Assembly.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.7b04420
Abstract: A combination of metal-organic self-assembly and reversible imine formation is used to achieve an organic synthesis via the solid state. Imine bond formation is employed to install a pyridyl to the alkene trans-cinnamaldehyde while Ag(I)… read more here.
Keywords: solid state; organic self; metal organic; formation ... See more keywords
Application of a tetrapyrimidyl cyclobutane synthesized in the organic solid state: a halogen-bonded supramolecular ladder
Sign Up to like & getrecommendations! Published in 2020 at "CrystEngComm"
DOI: 10.1039/d0ce01280g
Abstract: A halogen-bonded supramolecular ladder comprised of a novel pyrimidine-based cyclobutane photoproduct synthesized in the organic solid state via a [2 + 2] photoreaction is reported. The photoproduct rctt-tetrakis(5′-pyrimidyl)cyclobutane functions as rungs while the linear divergent… read more here.
Keywords: halogen bonded; supramolecular ladder; synthesized organic; bonded supramolecular ... See more keywords
A rigid plant oil-based thermoset with a furfural-derived cyclobutane cross-linker
Sign Up to like & getrecommendations! Published in 2021 at "Green Chemistry"
DOI: 10.1039/d0gc04323k
Abstract: Bio-based hardeners that are not amine or anhydride based are of particular interest to avoid associated health concerns. In the present study, a recently developed furfural-based cross-linker bearing a semi-rigid cyclobutane moiety is investigated for… read more here.
Keywords: cyclobutane; based thermoset; oil; cross ... See more keywords
On the planarity of the cyclobutane ring in the crystal of dimethyl 2,4-bis(3,4-dimethoxyphenyl)cyclobutane-1,3-dicarboxylate: a natural bond orbital and Hirshfeld surface analysis study
Sign Up to like & getrecommendations! Published in 2020 at "New Journal of Chemistry"
DOI: 10.1039/d0nj02739a
Abstract: Dimethyl 2,4-bis(3,4-dimethoxyphenyl)cyclobutane-1,3-dicarboxylate was synthesized by the dimerization of methyl 3-(3,4-dimethoxyphenyl)acrylate in methanol under photoirradiation by direct sunlight. Its molecular and crystal structures were determined by single crystal X-ray analysis. The molecule is located at the… read more here.
Keywords: dimethoxyphenyl cyclobutane; dimethoxyphenyl; analysis; bis dimethoxyphenyl ... See more keywords
From energy to electron transfer photocatalysis (PenT → PET): oxidative cyclobutane cleavage alters the product composition.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d2cc04693h
Abstract: Photocatalytic [2+2]-cycloadditions between cyclic enones and electron-rich cyclic enol ethers are initiated by triplet-triplet energy transfer from an excited iridium photocatalyst to the enone acceptor. The composition of the resulting cycloadduct mixture shows a surprising… read more here.
Keywords: transfer; cyclobutane; composition; energy ... See more keywords
Synthesis of Bis(amino acids) Containing the Styryl-cyclobutane Core by Photosensitized [2+2]-Cross-cycloaddition of Allylidene-5(4H)-oxazolones
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24087583
Abstract: The irradiation of 2-aryl-4-(E-3′-aryl-allylidene)-5(4H)-oxazolones 1 with blue light (456 nm) in the presence of [Ru(bpy)3](BF4)2 (bpy = 2,2′-bipyridine, 5% mol) gives the unstable cyclobutane-bis(oxazolones) 2 by [2+2]-photocycloaddition of two oxazolones 1. Each oxazolone contributes to… read more here.
Keywords: amino acids; cyclobutane; bis amino; styryl cyclobutane ... See more keywords