Visual detection of cyclobutane pyrimidine dimer DNA damage lesions by Hg2+ and carbon dots.
Sign Up to like & getrecommendations! Published in 2018 at "Analytica chimica acta"
DOI: 10.1016/j.aca.2018.02.029
Abstract: Cyclobutane pyrimidine dimmers (CPDs) and 6-4-[pyrimidine-2'-one] pyrimidine (6-4 PP) are major UV induced DNA damage lesions formed from solar radiation and other sources. CPD lesions are presumably mutagenic and carcinogenic that inhibit polymerases and interfere in… read more here.
Keywords: cpd; dna damage; detection; cyclobutane pyrimidine ... See more keywords
Structural basis of cyclobutane pyrimidine dimer recognition by UV-DDB in the nucleosome
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-65486-5
Abstract: In mammalian global genomic nucleotide excision repair, UV-DDB plays a central role in recognizing DNA lesions, such as 6-4 photoproducts and cyclobutane pyrimidine dimers, within chromatin. In the present study, we perform cryo-electron microscopy analyses… read more here.
Keywords: ddb nucleosome; cyclobutane pyrimidine; pyrimidine dimer; pyrimidine ... See more keywords
Vitamin E inhibits the UVAI induction of “light” and “dark” cyclobutane pyrimidine dimers, and oxidatively generated DNA damage, in keratinocytes
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-18924-4
Abstract: Solar ultraviolet radiation (UVR)-induced DNA damage has acute, and long-term adverse effects in the skin. This damage arises directly by absorption of UVR, and indirectly via photosensitization reactions. The aim of the present study was… read more here.
Keywords: dna damage; cyclobutane pyrimidine; damage keratinocytes; damage ... See more keywords
The UV/Visible Radiation Boundary Region (385–405 nm) Damages Skin Cells and Induces “dark” Cyclobutane Pyrimidine Dimers in Human Skin in vivo
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-30738-6
Abstract: The adverse effects of terrestrial solar ultraviolet radiation (UVR) (~295–400 nm) on the skin are well documented, especially in the UVB region (~295–320 nm). The effects of very long-wave UVA (>380 nm) and visible radiation (≥400 nm) are much less… read more here.
Keywords: visible radiation; cyclobutane pyrimidine; skin; region ... See more keywords
Dynamics of transcription-coupled repair of cyclobutane pyrimidine dimers and (6-4) photoproducts in Escherichia coli
Sign Up to like & getrecommendations! Published in 2024 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2416877121
Abstract: Significance Ultraviolet (UV) light induces principally cyclobutane pyrimidine dimers (CPDs) and (6-4) photoproducts [(6-4)PPs] in DNA. Both are excised from bacterial genomes by UvrABC excision nuclease. Due to relative helical distortion, (6-4)PPs are recognized and… read more here.
Keywords: pyrimidine dimers; dynamics transcription; cyclobutane pyrimidine; repair ... See more keywords
Poaceae plants transfer cyclobutane pyrimidine dimer photolyase to chloroplasts for ultraviolet-B resistance
Sign Up to like & getrecommendations! Published in 2024 at "Plant Physiology"
DOI: 10.1093/plphys/kiae060
Abstract: Abstract Photoreactivation enzyme that repairs cyclobutane pyrimidine dimer (CPD) induced by ultraviolet-B radiation, commonly called CPD photolyase (PHR) is essential for plants living under sunlight. Rice (Oryza sativa) PHR (OsPHR) is a unique triple-targeting protein.… read more here.
Keywords: cyclobutane pyrimidine; pyrimidine dimer; poaceae plants; photolyase ... See more keywords
Cyclobutane Pyrimidine Dimer Hyperhotspots as Sensitive Indicators of Keratinocyte UV Exposure †
Sign Up to like & getrecommendations! Published in 2022 at "Photochemistry and Photobiology"
DOI: 10.1111/php.13683
Abstract: The dominant DNA damage generated by UV exposure is the cyclobutane pyrimidine dimer (CPD), which alters skin cell physiology and induces cell death and mutation. Genome‐wide nucleotide‐resolution analysis of CPDs in melanocytes and fibroblasts has… read more here.
Keywords: exposure; sensitive indicators; cpd hyperhotspots; cyclobutane pyrimidine ... See more keywords
The Role of Acetyl Zingerone and Its Derivatives in Inhibiting UV-Induced, Incident, and Delayed Cyclobutane Pyrimidine Dimers
Sign Up to like & getrecommendations! Published in 2023 at "Antioxidants"
DOI: 10.3390/antiox12020278
Abstract: Cyclobutane pyrimidine dimers (CPDs) are ultraviolet radiation (UV)-induced carcinogenic DNA photoproducts that lead to UV signature mutations in melanoma. Previously, we discovered that, in addition to their incident formation (iCPDs), UV exposure induces melanin chemiexcitation… read more here.
Keywords: dcpds; cyclobutane pyrimidine; acetyl zingerone; pyrimidine dimers ... See more keywords