Cyclocreatine Transport by SLC6A8, the Creatine Transporter, in HEK293 Cells, a Human Blood-Brain Barrier Model Cell, and CCDSs Patient-Derived Fibroblasts
Sign Up to like & getrecommendations! Published in 2020 at "Pharmaceutical Research"
DOI: 10.1007/s11095-020-2779-0
Abstract: Cyclocreatine, a creatine analog, is a candidate drug for treating patients with cerebral creatine deficiency syndromes (CCDSs) caused by creatine transporter (CRT, SLC6A8) deficiency, which reduces brain creatine level. The purpose of this study was… read more here.
Keywords: creatine; ccdss patient; hek293 cells; cyclocreatine ... See more keywords
Quantification of cyclocreatine in mouse and rat plasma using hydrophilic‐interaction ultra‐performance liquid chromatography‐tandem mass spectrometry
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Pharmaceutical and Biomedical Analysis"
DOI: 10.1016/j.jpba.2017.07.049
Abstract: HighlightsRapid, selective, accurate and reproducible HILIC UPLC–MS/MS method to quantify cyclocreatine was developed.Method provided good retention of cyclocreatine with no interference from mouse and rat plasma.The pharmacokinetic parameters of cyclocreatine after oral administration are reported.… read more here.
Keywords: cyclocreatine; rat plasma; plasma; mouse rat ... See more keywords