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Published in 2020 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2020.119391
Abstract: The antipsychotic drug chlorpromazine (CPZ) has potential for the treatment of acute myeloid leukemia, if central nervous system side-effects resulting from its passage through the blood-brain barrier can be prevented. A robust drug delivery system…
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Keywords:
chlorpromazine;
complexation;
drug;
cyclodextrin complexation ... See more keywords
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Published in 2022 at "Acta crystallographica. Section C, Structural chemistry"
DOI: 10.1107/s2053229622004004
Abstract: 4-Chloro-17β-hydroxy-17α-methylandrosta-1,4-dien-3-one (C20H27ClO2), known as turinabol, is a synthetic anabolic-androgenic agent which belongs to the steroid class. Recrystallization from various solvents was performed and the following new solid forms of turinabol were obtained: the hemihydrate (C20H27ClO2·0.5H2O),…
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Keywords:
cyclodextrin complexation;
solid forms;
c20h27clo2;
forms cyclodextrin ... See more keywords
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Published in 2018 at "Drug Design, Development and Therapy"
DOI: 10.2147/dddt.s157611
Abstract: Introduction Toltrazuril (Tol) is used to prevent and combat coccidiosis. However, its low aqueous solubility and poor oral bioavailability limit clinical application. Methods To overcome the shortcomings, toltrazuril–hydroxypropyl–β-cyclodextrin inclusion complex (Tol-HP-β-CD) was prepared and characterized.…
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Keywords:
complexation toltrazuril;
bioavailability;
hydroxypropyl cyclodextrin;
tol ... See more keywords
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Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics14071329
Abstract: Solvent-free preparation types for cyclodextrin complexation, such as co-grinding, are technologies desired by the industry. However, in-depth analytical evaluation of the process and detailed characterization of intermediate states of the complexes are still lacking in…
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Keywords:
cyclodextrin complexation;
complexation;
complexation fenofibrate;
process ... See more keywords