A Synthetic Strategy toward Eight-Membered Cyclic Amines by Cycloetherification and Claisen Rearrangement.
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DOI: 10.1021/acs.orglett.1c00763
Abstract: Eight-membered nitrogen-containing heterocycles were straightforwardly produced by a nickel-catalyzed cycloetherification and subsequent Claisen rearrangement of secondary and tertiary alcohols. In particular, a one-pot transformation was achieved with tertiary alcohols in moderate to good yields. This… read more here.
Keywords: claisen rearrangement; synthetic strategy; cycloetherification; eight membered ... See more keywords