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Published in 2023 at "ACS Omega"
DOI: 10.1021/acsomega.2c07585
Abstract: The abnormal expression of the c-Met tyrosine kinase has been linked to the proliferation of several human cancer cell lines, including non-small-cell lung cancer (NSCLC). In this context, the identification of new c-Met inhibitors based…
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Keywords:
structure;
qsar modeling;
cyclohexane dione;
adme tox ... See more keywords
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Published in 2017 at "New Journal of Chemistry"
DOI: 10.1039/c6nj03835b
Abstract: The reported syntheses of alleged functionalised 1,2,3-triazines from cyclohexane-1,2-dione and aryl azides, in the presence of pyrrolidine and other amines, were repeated. The products do not contain the bicyclic triazine and bicyclic ketone moieties; instead,…
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Keywords:
aryl azides;
usual unusual;
cyclohexane dione;
dione aryl ... See more keywords
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0
Published in 2019 at "Synthetic Communications"
DOI: 10.1080/00397911.2019.1606920
Abstract: Abstract Here in, we described the synthesis of novel bisheterocycles imidazopyridine bearing xanthenedione by reacting various substituted 2-phenylimidazo [1,2-a] pyridine-3-carbaldehyde with cyclohexane-1,3-dione in gluconic acid aqueous solution (GAAS) via a tandem Knoevenagel followed by Michael,…
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Keywords:
novel;
pyridine carbaldehyde;
phenylimidazo pyridine;
gluconic acid ... See more keywords
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Published in 2020 at "Synthetic Communications"
DOI: 10.1080/00397911.2020.1791343
Abstract: Abstract Herein, we report the first synthesis and characterization of 2-(2,2,2-trifluoro-1-aryl-ethylidene)cyclohexane-1,3-dione (4a–4t, upto 80%) via a two-step procedure starting from 1,3-cyclohexanedione (2a–2e) and trifluoroacetophenones (1a–1d). The product formation was found to be dependent on various…
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Keywords:
aryl ethylidene;
trifluoro aryl;
ethylidene cyclohexane;
cyclohexane dione ... See more keywords
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Published in 2022 at "Acta Crystallographica Section E: Crystallographic Communications"
DOI: 10.1107/s2056989022009872
Abstract: In the title compound, the dihedral angle between the mean planes of the cyclohexane and 1,3-dithietane rings is 9.1 (3)°. A short S⋯O contact is observed in the crystal.
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Keywords:
dithietan ylidene;
synthesis crystal;
cyclohexane dione;
structure dithietan ... See more keywords
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Published in 2022 at "Acta chimica Slovenica"
DOI: 10.17344/acsi.2021.6886
Abstract: 2-Amino-6-oxo-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carbonitrile (3) was prepared from the reaction of cyclohexane-1,4-dione with elemental sulfur and malononitrile in 1,4-dioxane and triethylamine as catalyst. The latter compound reacted with triethyl orthoformate and either malononitrile or ethyl cyanoacetate in 1,4-dioxane…
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Keywords:
cancer activities;
antiprostate cancer;
dione;
antiproliferative antiprostate ... See more keywords