Synthesis of 4-hetero-16α,17α-cyclohexanopregnanes and evaluation of their cytotoxicity against the HeLa cell line
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DOI: 10.1007/s11172-018-2336-8
Abstract: The oxidation of the ring A of 16α,17α-cyclohexanoprogesterone gave 5-oxo-A-nor-3,5-secopregnan-3-oic acid. The subsequent ring A closure in the latter compound upon treatment with sodium acetate in Ac2O afforded 4-oxasteroid. The reaction with ammonium acetate in… read more here.
Keywords: evaluation cytotoxicity; cytotoxicity hela; cyclohexanopregnanes evaluation; synthesis hetero ... See more keywords