Discovery and Biosynthesis of Glycosylated Cycloheximide from a Millipede-Associated Actinomycete.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of natural products"
DOI: 10.1021/acs.jnatprod.2c00951
Abstract: Chemical redundancy of microbial natural products (NPs) underscores the importance to exploit new resources of microorganisms. Insect-associated microbes are prolific but largely underexplored sources of diverse NPs. Herein, we discovered the new compound α-l-rhamnosyl-actiphenol (1)… read more here.
Keywords: discovery biosynthesis; glycosylated cycloheximide; millipede associated; cycloheximide ... See more keywords
Strong and widespread cycloheximide resistance in Stichococcus-like eukaryotic algal taxa
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DOI: 10.1038/s41598-022-05116-y
Abstract: This study was initiated following the serendipitous discovery of a unialgal culture of a Stichococcus -like green alga (Chlorophyta) newly isolated from soil collected on Signy Island (maritime Antarctica) in growth medium supplemented with 100 µg/mL… read more here.
Keywords: chx; resistance; stichococcus like; cycloheximide ... See more keywords
The Bul1/2 Alpha-Arrestins Promote Ubiquitylation and Endocytosis of the Can1 Permease upon Cycloheximide-Induced TORC1-Hyperactivation
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DOI: 10.3390/ijms221910208
Abstract: Selective endocytosis followed by degradation is a major mechanism for downregulating plasma membrane transporters in response to specific environmental cues. In Saccharomyces cerevisiae, this endocytosis is promoted by ubiquitylation catalyzed by the Rsp5 ubiquitin-ligase, targeted… read more here.
Keywords: can1; ubiquitylation; bul1; alpha arrestins ... See more keywords
The Yeast Permease Agp2 Senses Cycloheximide and Undergoes Degradation That Requires the Small Protein Brp1-Cellular Fate of Agp2 in Response to Cycloheximide
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24086975
Abstract: The Saccharomyces cerevisiae Agp2 is a plasma membrane protein initially reported to be an uptake transporter for L-carnitine. Agp2 was later rediscovered, together with three additional proteins, Sky1, Ptk2, and Brp1, to be involved in… read more here.
Keywords: agp2; chx; brp1; fate agp2 ... See more keywords