Chiral Cyclohexyl-Fused Spirobiindanes: Practical Synthesis, Ligand Development, and Asymmetric Catalysis.
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DOI: 10.1021/jacs.8b07125
Abstract: 1,1'-Spirobiindane has been one type of privileged skeleton for chiral ligand design, and 1,1'-spirobiindane-based chiral ligands have demonstrated outstanding performance in various asymmetric catalysis. However, the access to enantiopure spirobiindane is quite tedious, which obstructs… read more here.
Keywords: cyclohexyl; cyclohexyl fused; spirobiindane; ligand ... See more keywords
A Cyclohexyl-Fused Spirobiindane-derived Phosphine-catalyzed Synthesis of Tricyclic γ-Lactams and Kinetic Resolution of γ-Substituted Allenoates.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.9b07418
Abstract: A C2-symmetric chiral phosphine catalyst, NUSIOC-Phos, which can be easily derived from cyclohexyl-fused spirobiindane was introduced. A highly enantioselective domino process involving pyrrolidine-2,3-diones and γ-substituted alleno-ates catalyzed by NUSIOC-Phos has been disclosed. Diastereospecific tricyclic γ-lactams… read more here.
Keywords: cyclohexyl fused; fused spirobiindane; tricyclic lactams; kinetic resolution ... See more keywords