Discovery and Characterization of Pyridoxal 5'-Phosphate-Dependent Cycloleucine Synthases.
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DOI: 10.1021/jacs.4c02142
Abstract: Pyridoxal 5'-phosphate (PLP)-dependent enzymes are the most versatile biocatalysts for synthesizing nonproteinogenic amino acids. α,α-Disubstituted quaternary amino acids, such as 1-aminocyclopentane-1-carboxylic acid (cycloleucine), are useful building blocks for pharmaceuticals. In this study, starting with the… read more here.
Keywords: pyridoxal phosphate; cycloleucine synthases; plp dependent; cycloleucine ... See more keywords