Design, synthesis, and biological evaluation of new pyrazino[1,2‐a]benzimidazole derivatives as selective cyclooxygenase (COX‐2) inhibitors
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DOI: 10.1002/ardp.201800265
Abstract: A new class of pyrazino[1,2‐a]benzimidazole derivatives possessing the SO2Me pharmacophore at the para position of the C‐3 phenyl ring was designed, synthesized, and tested for their cyclooxygenase‐2 (COX‐2) inhibitory, anti‐cancer and anti‐platelet aggregation activities. In… read more here.
Keywords: pyrazino benzimidazole; cox; cyclooxygenase cox; benzimidazole derivatives ... See more keywords
The Search for Cyclooxygenase-2 (COX-2) Inhibitors for the Treatment of Inflammation Disease: An in-silico Study
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DOI: 10.2147/jmdh.s359429
Abstract: Purpose Cyclooxygenase (COX-2) has been validated as a molecular target for treating inflammatory diseases. The present work was performed to identify potential COX-2 inhibitors by employing pharmacophore modeling. Methods The pharmacophore features consisted of seven… read more here.
Keywords: kcal mol; cyclooxygenase cox; cox inhibitors; cox ... See more keywords
Cyclooxygenase-1 (COX-1) and COX-1 Inhibitors in Cancer: A Review of Oncology and Medicinal Chemistry Literature
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DOI: 10.3390/ph11040101
Abstract: Prostaglandins and thromboxane are lipid signaling molecules deriving from arachidonic acid by the action of the cyclooxygenase isoenzymes COX-1 and COX-2. The role of cyclooxygenases (particularly COX-2) and prostaglandins (particularly PGE2) in cancer-related inflammation has… read more here.
Keywords: chemistry; cyclooxygenase cox; cox; cancer ... See more keywords