Ductus Arteriosus of Extremely Preterm Twins is More Resistant to Cyclooxygenase Inhibitors Than Those of Singletons
Sign Up to like & getrecommendations! Published in 2021 at "Pediatric Cardiology"
DOI: 10.1007/s00246-021-02765-0
Abstract: Symptomatic patent ductus arteriosus (sPDA) is common among preterm infants, and can lead to several complications. This is particularly true for extremely preterm infants, as closure of the ductus arteriosus using cyclooxygenase inhibitors is often… read more here.
Keywords: extremely preterm; ductus arteriosus; arteriosus extremely; cyclooxygenase inhibitors ... See more keywords
Screening cyclooxygenase-2 inhibitors from Allium sativum L. compounds: in silico approach
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Molecular Modeling"
DOI: 10.1007/s00894-021-05016-4
Abstract: Inflammation is a natural protective response toward various simulators, including tissue damage or pathogens. The cyclooxygenase-2 (COX-2) is a very important protein in triggering pain and inflammation. Previous studies have claimed that Allium sativum offers… read more here.
Keywords: inhibitors allium; screening cyclooxygenase; allium sativum; cyclooxygenase inhibitors ... See more keywords
Computer-aided identification of natural lead compounds as cyclooxygenase-2 inhibitors using virtual screening and molecular dynamic simulation
Sign Up to like & getrecommendations! Published in 2018 at "Computational biology and chemistry"
DOI: 10.1016/j.compbiolchem.2018.07.005
Abstract: In order to find more natural lead-compounds as inhibitors for Cyclooxygenase-2, the essential structural features for human cyclooxygenase-2 inhibitors and 3D-Quantitative structure activity relationship (3D-QSAR) model were carried out based on dataset from three confirmatory… read more here.
Keywords: cyclooxygenase inhibitors; lead compounds; aided identification; natural lead ... See more keywords
New selective cyclooxygenase-2 inhibitors from cyclocoumarol: Synthesis, characterization, biological evaluation and molecular modeling.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.01.054
Abstract: In this work, a serie of cyclocoumarol derivatives was designed, synthesized, characterized and studied for their potentialities as selective inhibitors of COX-2. All target compounds have been screened for their anti-inflammatory activity by the assay… read more here.
Keywords: cyclooxygenase inhibitors; new selective; selective cyclooxygenase; inhibitors cyclocoumarol ... See more keywords
Cyclooxygenase inhibitors impair CD4 T cell immunity and exacerbate Mycobacterium tuberculosis infection in aerosol-challenged mice
Sign Up to like & getrecommendations! Published in 2019 at "Communications Biology"
DOI: 10.1038/s42003-019-0530-3
Abstract: Tuberculosis, caused by infection with Mycobacterium tuberculosis (Mtb), kills over 1.6 million people each year despite availability of antibiotics. The increase in drug resistant Mtb strains is a major public health emergency and host-directed therapy… read more here.
Keywords: cyclooxygenase inhibitors; infection; tuberculosis infection; tuberculosis ... See more keywords
Neurobiology and Therapeutic Potential of Cyclooxygenase-2 (COX-2) Inhibitors for Inflammation in Neuropsychiatric Disorders
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Psychiatry"
DOI: 10.3389/fpsyt.2019.00605
Abstract: Neuropsychiatric disorders, such as depression, bipolar disorder, schizophrenia, obsessive-compulsive disorder, and neurodevelopmental disorders such as autism spectrum disorder, are associated with significant illness burden. Accumulating evidence supports an association between these disorders and inflammation. Consequently,… read more here.
Keywords: cyclooxygenase inhibitors; neurobiology therapeutic; therapeutic potential; neurobiology ... See more keywords