Synthesis of C-Nor-D-homo-steroidal Alkaloids and Their Derivatives
Sign Up to like & getrecommendations! Published in 2018 at "Synthesis"
DOI: 10.1055/s-0036-1591965
Abstract: The C-nor-D-homo-steroidal alkaloid cyclopamine was discovered in the 1969 and in 2000 it was shown to act as an inhibitor of the hedgehog signaling (Hh) pathway, which is aberrantly activated in some tumors. Subsequently it… read more here.
Keywords: homo steroidal; homo; cyclopamine; synthesis homo ... See more keywords
Cyclopamine sensitizes multiple myeloma cells to circularly permuted TRAIL-induced apoptosis.
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DOI: 10.3892/ol.2021.12556
Abstract: Tumor necrosis factor related apoptosis inducing ligand (TRAIL) is a promising anti-myeloma drug prototype. The aim of the present study was to investigate the synergistic effects of cyclopamine and circularly permuted TRAIL (CPT) on the… read more here.
Keywords: apoptosis; cpt; cyclopamine; proliferation ... See more keywords