Divergent and gram-scale syntheses of (–)-veratramine and (–)-cyclopamine
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-49748-2
Abstract: Veratramine and cyclopamine, two of the most representative members of the isosteroidal alkaloids, are valuable molecules in agricultural and medicinal chemistry. While plant extraction of these compounds suffers from uncertain supply, efficient chemical synthesis approaches… read more here.
Keywords: divergent gram; chemistry; syntheses veratramine; veratramine cyclopamine ... See more keywords
The sonic hedgehog signaling inhibitor cyclopamine improves pulmonary arterial hypertension via regulating the bone morphogenetic protein receptor 2 pathway
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-97627-7
Abstract: Pulmonary arterial hypertension (PAH) is a severe and progressive disease with hallmarks of pulmonary vascular remodeling and bone morphogenetic protein receptor 2 (BMPR2) mutation. Recent studies indicate Sonic hedgehog (SHH) signaling is involved in the… read more here.
Keywords: bone morphogenetic; cyclopamine; protein; pulmonary arterial ... See more keywords
Synthesis of C-Nor-D-homo-steroidal Alkaloids and Their Derivatives
Sign Up to like & getrecommendations! Published in 2018 at "Synthesis"
DOI: 10.1055/s-0036-1591965
Abstract: The C-nor-D-homo-steroidal alkaloid cyclopamine was discovered in the 1969 and in 2000 it was shown to act as an inhibitor of the hedgehog signaling (Hh) pathway, which is aberrantly activated in some tumors. Subsequently it… read more here.
Keywords: homo steroidal; homo; cyclopamine; synthesis homo ... See more keywords
Abstract 6886: Pharmacokinetics of paclitaxel and cyclopamine co-administered via polymeric micelle in HCC mice
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-6886
Abstract: Hepatocellular Carcinoma (HCC) is a highly aggressive form of liver cancer that is typically diagnosed at an advanced stage, leaving limited treatment options. The current non-surgical, first-line treatment, Sorafenib, is non-curative and does not improve… read more here.
Keywords: mice; ptx; hcc; cyclopamine ... See more keywords
Cyclopamine sensitizes multiple myeloma cells to circularly permuted TRAIL-induced apoptosis.
Sign Up to like & getrecommendations! Published in 2021 at "Oncology letters"
DOI: 10.3892/ol.2021.12556
Abstract: Tumor necrosis factor related apoptosis inducing ligand (TRAIL) is a promising anti-myeloma drug prototype. The aim of the present study was to investigate the synergistic effects of cyclopamine and circularly permuted TRAIL (CPT) on the… read more here.
Keywords: apoptosis; cpt; cyclopamine; proliferation ... See more keywords