Catalytic asymmetric dipolar cycloadditions of indolyl delocalized metal-allyl species for the enantioselective synthesis of cyclopenta [b]indoles and pyrrolo[1,2-a]indoles
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DOI: 10.1007/s11426-020-9854-3
Abstract: The development of novel synthons and efficient methods to synthesize chiral polycyclic indoles has been a hot topic in organic synthesis and medicinal chemistry owing to their broad applications in medicines, pesticides, and other functional… read more here.
Keywords: chemistry; cyclopenta indoles; allyl species; metal allyl ... See more keywords
Brønsted acid promoted C–C bond formation between indolylmethyl electrophiles and ketene dithioacetals: Diastereoselective synthesis of highly functionalized cyclopenta[b]indoles
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DOI: 10.1016/j.tetlet.2020.152349
Abstract: Abstract A Bronsted-acid promoted method for the construction of carbon-carbon bonds between α-substituted indolylmethyl electrophiles and ketene dithioacetals is described. This strategy was utilized to access 2,3-disubstituted cyclopenta[b]indoles via formal [3+2] cycloadditions. Readily available indolyl… read more here.
Keywords: carbon; indolylmethyl electrophiles; cyclopenta indoles; acid promoted ... See more keywords