Polyhydroxylated Cyclopentane β-Amino Acids Derived from d-Mannose and d-Galactose: Synthesis and Protocol for Incorporation into Peptides
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DOI: 10.1021/acsomega.1c05468
Abstract: A stereoselective synthesis of polyhydroxylated cyclopentane β-amino acids from hexoses is reported. The reaction sequence comprises, as key steps, ring-closing metathesis of a polysubstituted diene intermediate followed by the stereoselective aza-Michael functionalization of the resulting… read more here.
Keywords: cyclopentane amino; protocol incorporation; amino acids; mannose galactose ... See more keywords