Synthetic Study on Pactamycin: Stereoselective Synthesis of the Cyclopentane Core Framework.
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DOI: 10.1021/acs.orglett.7b01257
Abstract: The cyclopentane core framework 23 of pactamycin (1) was synthesized in 14 steps from symmetric cyclohexadiene 11. Our synthetic strategy features Rh-mediated catalytic desymmetrization of 10 via aziridination and then regioselective ring-opening reaction of sulfonylaziridine… read more here.
Keywords: cyclopentane core; core framework; synthetic study;