1D Co(II) coordination polymers based on cyclobutyl- and cyclopentyl-substituted zoledronate analogues: synthesis, structural comparison, thermal stability and magnetic properties
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DOI: 10.1039/c8nj00118a
Abstract: Two novel derivatives of zoledronic acid (1-hydroxy-2-[1-(1H-imidazol-1-yl)cyclobutyl]ethylidene-1,1-diphosphonic acid (H4cbtZol) and 1-hydroxy-2-[1-(1H-imidazol-1-yl)cyclopentyl]ethylidene-1,1-diphosphonic acid (H4cptZol)) were synthesized, crystallized from water solutions as H4cbtZol·H2O (1) and H4cptZol·4H2O (2), and characterized by single-crystal X-ray diffraction. The reactions of H4cbtZol… read more here.
Keywords: cyclopentyl; magnetic properties; co2; coordination polymers ... See more keywords
Metabolism and excretion of (S)-6-(3-cyclopentyl-2-(4-trifluoromethyl)-1H-imidazol-1-yl)propanamido)nicotinic acid (PF-04991532), a hepatoselective glucokinase activator, in humans: confirmation of the MIST potential noted in first-in-Human metabolite scouting studies
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DOI: 10.1080/00498254.2019.1581960
Abstract: Abstract 1. The absorption, metabolism, and excretion of a single oral 450-mg dose of [14C]-(S)-6-(3-cyclopentyl-2-(4-trifluoromethyl)-1H-imidazol-1-yl)propanamido)nicotinic acid (PF-04991532), a hepatoselective glucokinase activator, was investigated in humans. Mass balance was achieved with ∼94.6% of the administered dose… read more here.
Keywords: trifluoromethyl imidazol; imidazol propanamido; cyclopentyl; metabolism ... See more keywords