Extensive screening of cyclopeptide toxins in mushrooms by ultra-high-performance liquid chromatography coupled with quadrupole-Orbitrap mass spectrometry.
Sign Up to like & getrecommendations! Published in 2020 at "Food chemistry"
DOI: 10.1016/j.foodchem.2020.127146
Abstract: A non-target screening method of cyclopeptide toxins and their analogues in mushroom was developed, using ultra-high-performance liquid chromatography coupled with quadrupole Orbitrap mass spectrometry (UHPLC-Q-Orbitrap MS) followed by mass spectrometry databases retrieval and software tools… read more here.
Keywords: mass spectrometry; cyclopeptide toxins; ultra high; orbitrap ... See more keywords
Design and Discovery of Natural Cyclopeptide Skeleton Based Programmed Death Ligand-1 Inhibitor as Immune Modulator for Cancer Therapy.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.0c01262
Abstract: Blockade of immune checkpoint PD-1/PD-L1 facilitate the rescue of immune escapes of tumor cells. Though various of monoclonal antibodies have been approved for clinical therapy, the development of small molecular inhibitors lags behind antibodies partially… read more here.
Keywords: cyclopeptide; inhibitor; design; tumor cells ... See more keywords