Shape linear peptides into rigid rings: a sp3 C–H arylation approach to cyclophane-braced peptide macrocycles
Sign Up to like & getrecommendations! Published in 2018 at "Science China Chemistry"
DOI: 10.1007/s11426-018-9288-2
Abstract: Peptide-based therapeutics have attracted increasing attention due to their unique properties in comparison to small molecule drugs and recombinant biologics [1]. With moderate size and suitable surface area, peptides possess enormous potential in drug discovery… read more here.
Keywords: cyclophane braced; peptide macrocycles; braced peptide; arylation ... See more keywords
Completely o-Phenylene Bridged N4-Cyclophane: A Missing Link in the Phenylene Bridge N4-Cyclophane Family.
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DOI: 10.1021/acs.orglett.3c01326
Abstract: Unprecedented types of metal-free complete o-phenylene bridged N4-cyclophanes (M1 and M2) have been synthesized via sequential palladium-catalyzed Buchwald-Hartwig N-arylation reactions. These cyclophanes may be considered as aromatic analogues of aliphatic group-spaced N4-macrocycles. These have been… read more here.
Keywords: cyclophane missing; completely phenylene; phenylene bridged; cyclophane ... See more keywords
Supramolecular Mechanosensitive Potassium Channel Formed by Fluorinated Amphiphilic Cyclophane.
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DOI: 10.1021/jacs.2c04118
Abstract: Inspired by mechanosensitive potassium channels found in nature, we developed a fluorinated amphiphilic cyclophane composed of fluorinated rigid aromatic units connected via flexible hydrophilic octa(ethylene glycol) chains. Microscopic and emission spectroscopic studies revealed that the… read more here.
Keywords: potassium; fluorinated amphiphilic; mechanosensitive potassium; cyclophane ... See more keywords
Divinylanthracene-Containing Tetracationic Organic Cyclophane with Near-Infrared Photoluminescence.
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DOI: 10.1021/jacs.3c01244
Abstract: Near-infrared (NIR) light is known to have outstanding optical penetration in biological tissues and to be non-invasive to cells compared with visible light. These characteristics make NIR-specific light optimal for numerous biological applications, such as… read more here.
Keywords: photoluminescence; containing tetracationic; near infrared; tetracationic organic ... See more keywords
Stabilizing the Naphthalenediimide Radical within a Tetracationic Cyclophane.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.9b08926
Abstract: Organic radicals are of importance in developing smart materials that have paramagnetic and/or near-infrared optical properties. Their practical applications, however, are limited by the labile nature of the radicals. Here, we demonstrate that by using… read more here.
Keywords: tetracationic cyclophane; radical within; stabilizing naphthalenediimide; cyclophane ... See more keywords