Ablation of Cyclophilin D Results in an Activation of FAK, Akt, and ERK Pathways in the Mouse Heart
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.25947
Abstract: Cyclophilin D (CypD) is a mitochondrial chaperone that regulates the mitochondrial permeability transition pore. Metabolically, deletion of Ppif (the gene encoding CypD) in mice is associated with elevated levels of mitochondrial matrix Ca2+ that leads… read more here.
Keywords: akt; heart; cyclophilin; ppif ... See more keywords
Mitochondrial permeability transition in cardiac ischemia–reperfusion: whether cyclophilin D is a viable target for cardioprotection?
Sign Up to like & getrecommendations! Published in 2017 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-017-2502-4
Abstract: Growing number of studies provide strong evidence that the mitochondrial permeability transition pore (PTP), a non-selective channel in the inner mitochondrial membrane, is involved in the pathogenesis of cardiac ischemia–reperfusion and can be targeted to… read more here.
Keywords: cyclophilin; mitochondrial permeability; target; reperfusion ... See more keywords
Long-distance regulation of shoot gravitropism by Cyclophilin 1 in tomato (Solanum lycopersicum) plants.
Sign Up to like & getrecommendations! Published in 2020 at "Planta"
DOI: 10.1007/s00425-020-03448-5
Abstract: MAIN CONCLUSION The phloem-mobile protein SlCyp1 traffics to distant parts of the shoot to regulate its gravitropic response. In addition, SlCyp1 targets specific cells in the root to promote lateral root development. The tomato (Solanum… read more here.
Keywords: cyclophilin; lateral root; shoot gravitropism; slcyp1 ... See more keywords
Interaction of cyclophilin a and human coronavirus 229E N protein is essential for virus replication.
Sign Up to like & getrecommendations! Published in 2019 at "Antiviral research"
DOI: 10.1016/j.antiviral.2019.104620
Abstract: The well-known immunosuppressive drug cyclosporin A inhibits replication of various viruses including coronaviruses by binding to cellular cyclophilins thus inactivating their cis-trans peptidyl-prolyl isomerase function. Viral nucleocapsid proteins are inevitable for genome encapsidation and replication.… read more here.
Keywords: protein; cyclophilin; csa derivatives; interaction ... See more keywords
Biophysical and biochemical characterization of a thermostable archaeal cyclophilin from Methanobrevibacter ruminantium.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2019.07.149
Abstract: The archaeal protein folding machinery is quite similar to that found in eukaryotes, especially in terms of shared components like chaperones. Cyclophilins are chaperones found in both eukaryotes and archaea, which catalyze the reversible cis-trans… read more here.
Keywords: cyclophilin; characterization; methanobrevibacter ruminantium; archaeal cyclophilin ... See more keywords
The contribution of cyclophilin A to immune-mediated central nervous system inflammation
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Neuroimmunology"
DOI: 10.1016/j.jneuroim.2019.577118
Abstract: Cyclophilin A has multiple known functions in inflammation. Intracellular cyclophilin A modulates T helper 2 response (Th2) and extracellular cyclophilin A functions as a leukocyte chemotactic factor. The contribution of cyclophilin A to central nervous… read more here.
Keywords: cyclophilin knockout; contribution cyclophilin; cyclophilin; central nervous ... See more keywords
Proximal tubule cyclophilin D regulates fatty acid oxidation in cisplatin-induced acute kidney injury.
Sign Up to like & getrecommendations! Published in 2019 at "Kidney international"
DOI: 10.1016/j.kint.2019.08.019
Abstract: Regardless of the etiology, acute kidney injury involves aspects of mitochondrial dysfunction and ATP depletion. Fatty acid oxidation is the preferred energy source of the kidney and is inhibited during acute kidney injury. A pivotal… read more here.
Keywords: oxidation; cyclophilin; fatty acid; acute kidney ... See more keywords
Extracellular cyclophilin A induces cardiac hypertrophy via the ERK/p47phox pathway
Sign Up to like & getrecommendations! Published in 2020 at "Molecular and Cellular Endocrinology"
DOI: 10.1016/j.mce.2020.110990
Abstract: Excessive reactive oxygen species (ROS) are a critical driver of cardiac hypertrophy developing into heart failure. Cyclophilin A (CyPA), a member of the cyclophilin family, has been highlighted as a main secreted ROS-induced factor. The… read more here.
Keywords: cyclophilin; cardiac hypertrophy; hypertrophy via; extracellular cypa ... See more keywords
Peptidyl-prolyl isomerase and the biological activities of recombinant protein cyclophilin from Pyropia yezoensis (PyCyp).
Sign Up to like & getrecommendations! Published in 2020 at "Protein expression and purification"
DOI: 10.1016/j.pep.2020.105636
Abstract: Cyclophilins are highly conserved proteins associated with peptidyl-prolyl cis-trans isomerase activity (PPIase). The present study was designed to analyze the biological activity of recombinant cyclophilin from the marine red algae Pyropia yezoensis (PyCyp). The cyclophilin… read more here.
Keywords: cyclophilin; yezoensis; peptidyl prolyl; recombinant protein ... See more keywords
Furanoditerpenes from Spongia (Spongia) tubulifera Display Mitochondrial-Mediated Neuroprotective Effects by Targeting Cyclophilin D
Sign Up to like & getrecommendations! Published in 2022 at "ACS Chemical Neuroscience"
DOI: 10.1021/acschemneuro.2c00208
Abstract: Neuroprotective properties of five previously described furanoditerpenes 1–5, isolated from Spongia (Spongia) tubulifera, were evaluated in an in vitro oxidative stress model in SH-SY5Y cells. Dose–response treatments revealed that 1–5 improved cell survival at nanomolar… read more here.
Keywords: spongia spongia; mitochondrial mediated; mediated neuroprotective; cyclophilin ... See more keywords
Delineating a role for the Mitochondrial Permeability Transition Pore in Diabetic Kidney Disease by targeting Cyclophilin D.
Sign Up to like & getrecommendations! Published in 2020 at "Clinical science"
DOI: 10.1042/cs20190787
Abstract: Mitochondrial stress has been widely observed in Diabetic Kidney Disease (DKD). Cyclophilin D (CypD) is a functional component of the mitochondrial permeability transition pore (mPTP) which allows the exchange of ions and solutes between the… read more here.
Keywords: role; pathology; cyclophilin; diabetic kidney ... See more keywords