Rituximab vs Cyclophosphamide Induction Therapy for Patients With Granulomatosis With Polyangiitis
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.43799
Abstract: Key Points Question Is rituximab more effective than cyclophosphamide for treatment of granulomatosis with polyangiitis (GPA)? Findings In this comparativeness effectiveness study based on clinical data from 194 patients with GPA, rituximab as induction therapy… read more here.
Keywords: granulomatosis polyangiitis; induction therapy; cyclophosphamide;
Haploidentical Stem Cell Transplantation With Posttransplant Cyclophosphamide Therapy vs Other Donor Transplantations in Adults With Hematologic Cancers: A Systematic Review and Meta-analysis.
Sign Up to like & getrecommendations! Published in 2019 at "JAMA oncology"
DOI: 10.1001/jamaoncol.2019.3541
Abstract: Importance Use of haploidentical (HAPLO) stem cell transplantation with posttransplant cyclophosphamide is rapidly increasing in adults with hematologic cancers. However, its specific role compared with other transplant strategies has yet to be identified. Objective To… read more here.
Keywords: posttransplant cyclophosphamide; cell transplantation; stem cell; cyclophosphamide ... See more keywords
Busulfan-cyclophosphamide versus cyclophosphamide-busulfan as conditioning regimen before allogeneic hematopoietic cell transplantation: a prospective randomized trial
Sign Up to like & getrecommendations! Published in 2020 at "Annals of Hematology"
DOI: 10.1007/s00277-020-04312-y
Abstract: Busulfan and cyclophosphamide (BuCy) is a frequently used myeloablative conditioning regimen for allogeneic hematopoietic cell transplantation (allo-HCT). Theoretical considerations and pharmacological data indicate that application of busulfan prior to subsequent cyclophosphamide (BuCy) may trigger liver… read more here.
Keywords: busulfan; regimen allogeneic; allogeneic hematopoietic; conditioning regimen ... See more keywords
The multifactorial origin of posterior reversible encephalopathy syndrome in cyclophosphamide-treated lupus patients
Sign Up to like & getrecommendations! Published in 2017 at "Rheumatology International"
DOI: 10.1007/s00296-017-3843-x
Abstract: The cyclophosphamide as a predisposing factor for Posterior Reversible Encephalopathy Syndrome (PRES) and therapeutic option for systemic lupus erythematosus (SLE) is still confusing. The first and only case of PRES, probably induced by cyclophosphamide, in… read more here.
Keywords: encephalopathy syndrome; sle; posterior reversible; cyclophosphamide ... See more keywords
Role of Matrix Metalloproteinase-2 in the Development of Cyclophosphamide-Induced Cardiomyopathy
Sign Up to like & getrecommendations! Published in 2018 at "Bulletin of Experimental Biology and Medicine"
DOI: 10.1007/s10517-018-4017-x
Abstract: Immunohistochemical assay was employed to determine localization of MMP-2 in cardiomyocytes of WAG rats and changes in MMP-2 expression during modeled cardiomyopathy induced by single intraperitoneal injection of cyclophosphamide (125 mg/kg) alone or in combination… read more here.
Keywords: cardiomyocyte nuclei; cyclophosphamide induced; development cyclophosphamide; cyclophosphamide ... See more keywords
Multi-spectroscopic and HPLC Studies of the Interaction Between Estradiol and Cyclophosphamide With Human Serum Albumin: Binary and Ternary Systems
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Solution Chemistry"
DOI: 10.1007/s10953-017-0590-2
Abstract: Drug resistance is a phenomenon that frequently impairs a proper treatment of infections and cancer with chemotherapy. Multidrug efflux transporters extrude structurally dissimilar organic compounds often providing resistance to multiple toxic chemotherapeutic agents. The quantitative… read more here.
Keywords: drug; human serum; serum albumin; cyclophosphamide ... See more keywords
Cardioprotective Effects of Oroxylum indicum Extract Against Doxorubicin and Cyclophosphamide-Induced Cardiotoxicity.
Sign Up to like & getrecommendations! Published in 2021 at "Cardiovascular toxicology"
DOI: 10.1007/s12012-021-09701-x
Abstract: Administration of Chemotherapeutics, especially doxorubicin (DOX) and cyclophosphamide (CPS), is commonly associated with adverse effects such as myelosuppression and cardiotoxicity. At this time, few approved therapeutic options are currently available for the management of chemotherapy-associated… read more here.
Keywords: doxorubicin cyclophosphamide; induced cardiotoxicity; cyclophosphamide induced; cardioprotective effects ... See more keywords
Identification of potential genes associated with ALDH1A1 overexpression and cyclophosphamide resistance in chronic myelogenous leukemia using network analysis
Sign Up to like & getrecommendations! Published in 2021 at "Medical Oncology"
DOI: 10.1007/s12032-021-01569-9
Abstract: Cyclophosphamide (CP), an important alkylating agent which is used in the treatment therapy for chronic myeloid leukemia (CML). However, acquired drug resistance owing to the inactivation of its active metabolite aldophosphamide via tumoral-overexpressing aldehyde dehydrogenase… read more here.
Keywords: overexpression; network; aldh1a1 overexpression; analysis ... See more keywords
Cyclophosphamide-Induced Lung Injury
Sign Up to like & getrecommendations! Published in 2019 at "Kidney International Reports"
DOI: 10.1016/j.ekir.2018.11.001
Abstract: INTRODUCTION A ntineutrophil cytoplasmic antibody (ANCA) associated vasculitis is a multisystem autoimmune disease that often involves the lungs. It can be serious and sometimes fatal, and requires prompt recognition and treatment. Cyclophosphamide is a well-established… read more here.
Keywords: induced lung; lung injury; cyclophosphamide induced; cyclophosphamide ... See more keywords
Cyclophosphamide promotes the proliferation inhibition of mouse ovarian granulosa cells and premature ovarian failure by activating the lncRNA-Meg3-p53-p66Shc pathway.
Sign Up to like & getrecommendations! Published in 2017 at "Gene"
DOI: 10.1016/j.gene.2016.10.011
Abstract: The dysfunction of ovarian granulosa cells (OGCs) directly affects the premature ovarian failure (POF). In vivo experiments showed that cyclophosphamide significantly induced mouse ovarian atrophy and proliferation inhibition of OGCs. The expressions of p53, p66Shc… read more here.
Keywords: lncrna meg3; p53 p66shc; group; cyclophosphamide ... See more keywords
Glycosaminoglycan from Apostichopus japonicus induces immunomodulatory activity in cyclophosphamide-treated mice and in macrophages.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2019.02.093
Abstract: This study was designed to systematically elucidate the immunomodulation effect of glycosaminoglycan from Apostichopus japonicus (AHG) in cyclophosphamide (CY)-induced immunosuppression model and potential mechanism responsible for the activation of macrophages. The results showed that the… read more here.
Keywords: apostichopus japonicus; immunity; glycosaminoglycan apostichopus; cyclophosphamide ... See more keywords