Efficacy and tolerability of rituximab and reduced-dose cyclophosphamide, doxorubicin, vincristine, and prednisolone therapy for elderly patient with diffuse large B-cell lymphoma
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DOI: 10.1080/10245332.2018.1509461
Abstract: ABSTRACT Objectives: Chemoimmunotherapy with cyclophosphamide, doxorubicin, vincristine, and prednisolone combined with rituximab (R-CHOP) is currently the first-line therapy for diffuse large B-cell lymphoma (DLBCL). However, management of elderly patients is challenging and often requires dose… read more here.
Keywords: cyclophosphamide doxorubicin; reduced dose; vincristine prednisolone; doxorubicin vincristine ... See more keywords
TAp63 determines the fate of oocytes against DNA damage
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DOI: 10.1126/sciadv.ade1846
Abstract: Cyclophosphamide and doxorubicin lead to premature ovarian insufficiency as an off-target effect. However, their oocyte death pathway has been debated. Here, we clarified the precise mechanism of ovarian depletion induced by cyclophosphamide and doxorubicin. Dormant… read more here.
Keywords: cyclophosphamide doxorubicin; dna damage; tap63 determines; oocyte death ... See more keywords
Diffuse large B-cell lymphoma: 10 years' real-world clinical experience with rituximab plus cyclophosphamide, doxorubicin, vincristine and prednisolone
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DOI: 10.3892/ol.2018.7774
Abstract: Treatment with rituximab plus a regimen of cyclophosphamide, doxorubicin, vincristine and prednisolone (CHOP) for patients with diffuse large B-cell lymphoma (DLBCL) has proven efficacy in clinical trials. The present study investigated its application in clinical… read more here.
Keywords: cyclophosphamide doxorubicin; rituximab plus; vincristine prednisolone; diffuse large ... See more keywords