Role of Matrix Metalloproteinase-2 in the Development of Cyclophosphamide-Induced Cardiomyopathy
Sign Up to like & getrecommendations! Published in 2018 at "Bulletin of Experimental Biology and Medicine"
DOI: 10.1007/s10517-018-4017-x
Abstract: Immunohistochemical assay was employed to determine localization of MMP-2 in cardiomyocytes of WAG rats and changes in MMP-2 expression during modeled cardiomyopathy induced by single intraperitoneal injection of cyclophosphamide (125 mg/kg) alone or in combination… read more here.
Keywords: cardiomyocyte nuclei; cyclophosphamide induced; development cyclophosphamide; cyclophosphamide ... See more keywords
Cardioprotective Effects of Oroxylum indicum Extract Against Doxorubicin and Cyclophosphamide-Induced Cardiotoxicity.
Sign Up to like & getrecommendations! Published in 2021 at "Cardiovascular toxicology"
DOI: 10.1007/s12012-021-09701-x
Abstract: Administration of Chemotherapeutics, especially doxorubicin (DOX) and cyclophosphamide (CPS), is commonly associated with adverse effects such as myelosuppression and cardiotoxicity. At this time, few approved therapeutic options are currently available for the management of chemotherapy-associated… read more here.
Keywords: doxorubicin cyclophosphamide; induced cardiotoxicity; cyclophosphamide induced; cardioprotective effects ... See more keywords
Cyclophosphamide-Induced Lung Injury
Sign Up to like & getrecommendations! Published in 2019 at "Kidney International Reports"
DOI: 10.1016/j.ekir.2018.11.001
Abstract: INTRODUCTION A ntineutrophil cytoplasmic antibody (ANCA) associated vasculitis is a multisystem autoimmune disease that often involves the lungs. It can be serious and sometimes fatal, and requires prompt recognition and treatment. Cyclophosphamide is a well-established… read more here.
Keywords: induced lung; lung injury; cyclophosphamide induced; cyclophosphamide ... See more keywords
Polysaccharides from the flowers of tea (Camellia sinensis L.) modulate gut health and ameliorate cyclophosphamide-induced immunosuppression
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Functional Foods"
DOI: 10.1016/j.jff.2019.103470
Abstract: Abstract Polysaccharides are closely related to immune regulation, however, the effects of polysaccharides from different sources may be different. Therefore, the impact of a pectic heteropolysaccharides (TFPS) from the flowers of tea (Camellia sinensis L.)… read more here.
Keywords: camellia sinensis; gut health; flowers tea; cyclophosphamide induced ... See more keywords
Immunomodulatory activity of low molecular-weight peptides from Nibea japonica skin in cyclophosphamide-induced immunosuppressed mice
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Functional Foods"
DOI: 10.1016/j.jff.2020.103888
Abstract: In this study, a low molecular weight peptides fraction ( read more here.
Keywords: low molecular; nibea japonica; cyclophosphamide induced; weight ... See more keywords
Dendrobium sonia polysaccharide regulates immunity and restores the dysbiosis of the gut microbiota of the cyclophosphamide-induced immunosuppressed mice.
Sign Up to like & getrecommendations! Published in 2019 at "Chinese journal of natural medicines"
DOI: 10.1016/s1875-5364(19)30062-7
Abstract: To recognize the potential medicinal value of the Dendrobium sonia, polysaccharide (DSP) was extracted, purified, and investigated for its immunomodulatory activity. In vitro, DSP was shown to enhance the viability (MTT assay) and phagocytosis of… read more here.
Keywords: immunosuppressed mice; induced immunosuppressed; dendrobium sonia; sonia polysaccharide ... See more keywords
Mechanisms of Casein-Derived Immunomodulatory Peptides Maintaining Immune Homeostasis via Regulating Gut Microbiota in a Cyclophosphamide-Induced Mouse Model.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.5c07986
Abstract: Two immunomodulatory signature peptides (PFPEVFG and SPAQILQW) were obtained from casein hydrolysates produced by Kluyveromyces marxianus JY-1 in our previous studies with the aid of virtual screening. However, their mechanisms for improving the composition of… read more here.
Keywords: cyclophosphamide induced; gut microbiota; pfpevfg spaqilqw; peptides pfpevfg ... See more keywords
Tetrahedral-Framework Nucleic Acid Loaded with MicroRNA-155 Enhances Immunocompetence in Cyclophosphamide-Induced Immunosuppressed Mice by Modulating Dendritic Cells and Macrophages.
Sign Up to like & getrecommendations! Published in 2023 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.2c20657
Abstract: Nanomaterials are often used as immunomodulators because they can be tailored by a controllable process. In this work, a complex based on a tetrahedral framework nucleic acid delivery system and MicroRNA-155, known as T-155, is… read more here.
Keywords: induced immunosuppressed; tetrahedral framework; framework nucleic; nucleic acid ... See more keywords
Protective effects of herbal compounds against cyclophosphamide-induced organ toxicity: a pathway-centered approach
Sign Up to like & getrecommendations! Published in 2025 at "Drug and Chemical Toxicology"
DOI: 10.1080/01480545.2025.2455442
Abstract: Abstract Cyclophosphamide is a key component of numerous chemotherapeutic protocols, demonstrating broad-spectrum efficacy against various malignancies and non-cancerous conditions. This review examines CPM’s metabolic pathways, therapeutic applications, and its resulting organ-specific toxicities. Despite its clinical… read more here.
Keywords: protective effects; cyclophosphamide induced; compounds cyclophosphamide; toxicity ... See more keywords
Histological and flow cytometric evaluation of astaxanthin’s effects against cyclophosphamide induced heart injury in rats
Sign Up to like & getrecommendations! Published in 2025 at "Drug and Chemical Toxicology"
DOI: 10.1080/01480545.2025.2487865
Abstract: Abstract In this study, the protective effect of astaxanthin (AST) against cyclophosphamide (CP) induced adult rat heart damage was investigated. Eighteen rats were divided into 3 groups as Group 1: control, Group 2: cyclophosphamide and… read more here.
Keywords: heart; cyclophosphamide induced; histology; group ... See more keywords
Protective Effects of Antioxidants on Cyclophosphamide-Induced Ovarian Toxicity.
Sign Up to like & getrecommendations! Published in 2022 at "Biopreservation and biobanking"
DOI: 10.1089/bio.2021.0159
Abstract: The most common limitation of anticancer chemotherapy is the injury to normal cells. Cyclophosphamide, which is one of the most widely used alkylating agents, can cause premature ovarian insufficiency and infertility since the ovarian follicles… read more here.
Keywords: protective effects; effects antioxidants; toxicity; antioxidants cyclophosphamide ... See more keywords