Causes and possibilities to circumvent cyclophosphamide toxicity
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DOI: 10.1097/cad.0000000000000912
Abstract: Cyclophosphamide is an inert prodrug converted into 4-hydroxycyclophosphamide (OHCP) by hepatic hydroxylation. OHCP is in equilibrium with its tautomeric aldophosphamide (ALDO). From ALDO, the cytotoxic active metabolites are formed enzymatically by phosphodiesterases; these are the… read more here.
Keywords: toxicity; pam; causes possibilities; aldo ... See more keywords