Asymmetric Synthesis of Cyclobutanone via Lewis Acid Catalyzed Tandem Cyclopropanation/Semipinacol Rearrangement.
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DOI: 10.1021/jacs.8b06835
Abstract: Chiral Lewis acid catalyzed asymmetric formation of cyclobutanones from α-silyloxyacroleins and α-alkyl or α-aryl diazoesters has been developed. In the presence of a chiral oxazaborolidinium ion catalyst, various α-silyloxycyclobutanones possessing a chiral β-quaternary center were… read more here.
Keywords: lewis acid; tandem cyclopropanation; cyclopropanation semipinacol; semipinacol rearrangement ... See more keywords