Articles with "cyclopropane hydroxamic" as a keyword



In silico Design of Novel Histone Deacetylase 4 Inhibitors: Design Guidelines for Improved Binding Affinity

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Published in 2019 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms21010219

Abstract: Histone deacetylases (HDAC) are being targeted for a number of diseases such as cancer, inflammatory disease, and neurological disorders. Within this family of 18 isozymes, HDAC4 is a prime target for glioma, one of the… read more here.

Keywords: hdac4 inhibitors; hdac4; histone; design guidelines ... See more keywords