Pd(II)-Catalyzed Enantioselective C(sp3)–H Arylation of Cyclopropanes and Cyclobutanes Guided by Tertiary Alkylamines
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DOI: 10.1021/jacs.1c11921
Abstract: Strained aminomethyl-cycloalkanes are a recurrent scaffold in medicinal chemistry due to their unique structural features that give rise to a range of biological properties. Here, we report a palladium-catalyzed enantioselective C(sp3)–H arylation of aminomethyl-cyclopropanes and… read more here.
Keywords: cyclopropanes cyclobutanes; enantioselective sp3; tertiary alkylamines; sp3 arylation ... See more keywords