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   Articles with "cyclopropyl" as a keyword



Design, synthesis, antibacterial evaluation, molecular docking and computational study of 4-alkoxy/aryloxyphenyl cyclopropyl methane oxime derivatives

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recommendations! Published in 2021 at "Computational biology and chemistry"

DOI: 10.1016/j.compbiolchem.2021.107434

Abstract: A series of new 4-alkoxy/aryloxyphenyl cyclopropyl methane oxime derivatives 2(a-k) were synthesized and fully characterized by FT-IR, 1H-NMR, 13C-NMR and Mass spectrometry techniques. All the synthesized compounds 2(a-k) were assayed for in vitro antibacterial activity… read more here.

Keywords: cyclopropyl methane; alkoxy aryloxyphenyl; methane oxime; cyclopropyl ... See more keywords

Discovery and Mechanism of a Nematicide Candidate (W3): A Novel Amide Compound Containing a Cyclopropyl Moiety.

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recommendations! Published in 2024 at "Journal of agricultural and food chemistry"

DOI: 10.1021/acs.jafc.3c06696

Abstract: To find novel nematicides, we screened the nematicidal activity of compounds in our laboratory compound library. Interestingly, the compound N-((1R,2R)-2-(2-fluoro-4-(trifluoromethyl)phenyl)cyclopropyl)-2-(trifluoromethyl)benzamide (W3) showed a broad spectrum and excellent nematicidal activity. The LC50 values of compound W3… read more here.

Keywords: discovery mechanism; cyclopropyl; mechanism nematicide; compound ... See more keywords

CH Bond Activation of Unsaturated Hydrocarbons by a Niobium Methyl Cyclopropyl Precursor. Cyclopropyl Ring Opening and Alkyne Coupling Reaction

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recommendations! Published in 2017 at "Organometallics"

DOI: 10.1021/acs.organomet.6b00506

Abstract: The transient intermediate η2-cyclopropene/bicyclobutane niobium complex [TpMe2Nb(η2-c-C3H4)(MeCCMe)] A, generated by an intramolecular β-H abstraction of methane from the methyl cyclopropyl complex [TpMe2NbMe(c-C3H5)(MeCCMe)] (1), is able to cleave the CH bond of a variety of unsaturated… read more here.

Keywords: unsaturated hydrocarbons; meccme; bond; cyclopropyl ... See more keywords

Highly Enantioselective Synthesis of Chiral Cyclopropyl Nucleosides via Catalytic Asymmetric Intermolecular Cyclopropanation.

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recommendations! Published in 2017 at "Organic letters"

DOI: 10.1021/acs.orglett.7b03110

Abstract: An efficient route to construct chiral cyclopropyl purine nucleoside analogues has been established via the catalytic asymmetric Michael-initiated ring-closure reactions of α-purine acrylates with α-bromo-carboxylic esters. Using (DHQD)2AQN as the catalyst, various chiral cyclopropyl purine… read more here.

Keywords: via catalytic; cyclopropyl; chiral cyclopropyl; cyclopropyl purine ... See more keywords

Pd-Catalyzed Synthesis of Densely Functionalized Cyclopropyl Vinyl Sulfides Reveals the Origin of High Selectivity in a Fundamental Alkyne Insertion Step

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recommendations! Published in 2020 at "ACS Catalysis"

DOI: 10.1021/acscatal.0c02053

Abstract: Catalytic atom-economic hydrothiolation of cyclopropyl acetylenes was developed. Using Pd/NHC complex as a precatalyst, regioselective addition of thiols to cyclopropyl acetylenes was successfully ... read more here.

Keywords: densely functionalized; synthesis densely; cyclopropyl; functionalized cyclopropyl ... See more keywords

Structural, Biochemical, and Bioinformatic Basis for Identifying Radical SAM Cyclopropyl Synthases

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recommendations! Published in 2024 at "ACS Chemical Biology"

DOI: 10.1021/acschembio.3c00583

Abstract: The importance of radical S-adenosyl-l-methionine (RS) enzymes in the maturation of ribosomally synthesized and post-translationally modified peptides (RiPPs) continues to expand, specifically for the RS-SPASM subfamily. We recently discovered an RS-SPASM enzyme that installs a… read more here.

Keywords: structural biochemical; cyclopropyl synthases; bioinformatic basis; cyclopropyl ... See more keywords
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Enantioselective Hydrothiolation: Diverging Cyclopropenes through Ligand Control.

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recommendations! Published in 2021 at "Journal of the American Chemical Society"

DOI: 10.1021/jacs.1c00939

Abstract: In this article, we advance Rh-catalyzed hydrothiolation through the divergent reactivity of cyclopropenes. Cyclopropenes undergo hydrothiolation to provide cyclopropyl sulfides or allylic sulfides. The choice of bisphosphine ligand dictates whether the pathway involves ring-retention or… read more here.

Keywords: hydrothiolation diverging; diverging cyclopropenes; cyclopropenes ligand; cyclopropyl ... See more keywords

Lewis acid catalysed asymmetric cascade reaction of cyclopropyl ketones: concise synthesis of pyrrolobenzothiazoles.

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recommendations! Published in 2020 at "Chemical communications"

DOI: 10.1039/d0cc05667g

Abstract: Utilizing the C4 reactive site of cyclopropyl ketones and a chiral N,N'-dioxide-scandium(iii) complex as a catalyst, a concise ring-opening/cyclization/thio-Michael cascade method was developed for the synthesis of chiral benzothiazole derivatives from a simple 2-aminothiophenol material.… read more here.

Keywords: lewis acid; catalysed asymmetric; cyclopropyl; asymmetric cascade ... See more keywords

Tertiary cyclopropyl carbagermatranes: synthesis and cross-coupling.

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recommendations! Published in 2021 at "Chemical communications"

DOI: 10.1039/d1cc02930d

Abstract: The construction of the cyclopropyl quaternary carbon center can afford a series of 1,1-olefin bioisosteres. Here, we report tertiary cyclopropyl carbagermatranes, which can be easily obtained by the zinc-mediated decarboxylation of NHP esters. In addition,… read more here.

Keywords: tertiary cyclopropyl; cyclopropyl; carbagermatranes synthesis; cyclopropyl carbagermatranes ... See more keywords

Metal-Free Synthesis of Oxazinones and Their Reductive Ring Opening to Provide Cyclopropyl Carbinols

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recommendations! Published in 2017 at "Synthesis"

DOI: 10.1055/s-0036-1588748

Abstract: General routes for the synthesis of 1,3-oxazin-4-ones are discussed, with particular attention paid to recent developments in the field. The syntheses of amine functionalised cyclopropyl carbinols via a hydride-mediated reduction of various 5-chloroethyl-1,3-oxazin-4-enones in moderate… read more here.

Keywords: free synthesis; cyclopropyl; oxazinones reductive; synthesis oxazinones ... See more keywords

Preparation of Chiral Enantioenriched Densely Substituted Cyclopropyl Azoles, Amines, and Ethers via Formal SN2′ Substitution of Bromocylopropanes

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recommendations! Published in 2022 at "Molecules"

DOI: 10.3390/molecules27207069

Abstract: Enantiomerically enriched cyclopropyl ethers, amines, and cyclopropylazole derivatives possessing three stereogenic carbon atoms in a small cycle are obtained via the diastereoselective, formal nucleophilic substitution of chiral, non-racemic bromocyclopropanes. The key feature of this methodology… read more here.

Keywords: substitution; chiral enantioenriched; densely substituted; preparation chiral ... See more keywords