Design, synthesis, antibacterial evaluation, molecular docking and computational study of 4-alkoxy/aryloxyphenyl cyclopropyl methane oxime derivatives
Sign Up to like & getrecommendations! Published in 2021 at "Computational biology and chemistry"
DOI: 10.1016/j.compbiolchem.2021.107434
Abstract: A series of new 4-alkoxy/aryloxyphenyl cyclopropyl methane oxime derivatives 2(a-k) were synthesized and fully characterized by FT-IR, 1H-NMR, 13C-NMR and Mass spectrometry techniques. All the synthesized compounds 2(a-k) were assayed for in vitro antibacterial activity… read more here.
Keywords: cyclopropyl methane; alkoxy aryloxyphenyl; methane oxime; cyclopropyl ... See more keywords
CH Bond Activation of Unsaturated Hydrocarbons by a Niobium Methyl Cyclopropyl Precursor. Cyclopropyl Ring Opening and Alkyne Coupling Reaction
Sign Up to like & getrecommendations! Published in 2017 at "Organometallics"
DOI: 10.1021/acs.organomet.6b00506
Abstract: The transient intermediate η2-cyclopropene/bicyclobutane niobium complex [TpMe2Nb(η2-c-C3H4)(MeCCMe)] A, generated by an intramolecular β-H abstraction of methane from the methyl cyclopropyl complex [TpMe2NbMe(c-C3H5)(MeCCMe)] (1), is able to cleave the CH bond of a variety of unsaturated… read more here.
Keywords: unsaturated hydrocarbons; meccme; bond; cyclopropyl ... See more keywords
Highly Enantioselective Synthesis of Chiral Cyclopropyl Nucleosides via Catalytic Asymmetric Intermolecular Cyclopropanation.
Sign Up to like & getrecommendations! Published in 2017 at "Organic letters"
DOI: 10.1021/acs.orglett.7b03110
Abstract: An efficient route to construct chiral cyclopropyl purine nucleoside analogues has been established via the catalytic asymmetric Michael-initiated ring-closure reactions of α-purine acrylates with α-bromo-carboxylic esters. Using (DHQD)2AQN as the catalyst, various chiral cyclopropyl purine… read more here.
Keywords: via catalytic; cyclopropyl; chiral cyclopropyl; cyclopropyl purine ... See more keywords
Pd-Catalyzed Synthesis of Densely Functionalized Cyclopropyl Vinyl Sulfides Reveals the Origin of High Selectivity in a Fundamental Alkyne Insertion Step
Sign Up to like & getrecommendations! Published in 2020 at "ACS Catalysis"
DOI: 10.1021/acscatal.0c02053
Abstract: Catalytic atom-economic hydrothiolation of cyclopropyl acetylenes was developed. Using Pd/NHC complex as a precatalyst, regioselective addition of thiols to cyclopropyl acetylenes was successfully ... read more here.
Keywords: densely functionalized; synthesis densely; cyclopropyl; functionalized cyclopropyl ... See more keywords
Enantioselective Hydrothiolation: Diverging Cyclopropenes through Ligand Control.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.1c00939
Abstract: In this article, we advance Rh-catalyzed hydrothiolation through the divergent reactivity of cyclopropenes. Cyclopropenes undergo hydrothiolation to provide cyclopropyl sulfides or allylic sulfides. The choice of bisphosphine ligand dictates whether the pathway involves ring-retention or… read more here.
Keywords: hydrothiolation diverging; diverging cyclopropenes; cyclopropenes ligand; cyclopropyl ... See more keywords
Lewis acid catalysed asymmetric cascade reaction of cyclopropyl ketones: concise synthesis of pyrrolobenzothiazoles.
Sign Up to like & getrecommendations! Published in 2020 at "Chemical communications"
DOI: 10.1039/d0cc05667g
Abstract: Utilizing the C4 reactive site of cyclopropyl ketones and a chiral N,N'-dioxide-scandium(iii) complex as a catalyst, a concise ring-opening/cyclization/thio-Michael cascade method was developed for the synthesis of chiral benzothiazole derivatives from a simple 2-aminothiophenol material.… read more here.
Keywords: lewis acid; catalysed asymmetric; cyclopropyl; asymmetric cascade ... See more keywords
Tertiary cyclopropyl carbagermatranes: synthesis and cross-coupling.
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DOI: 10.1039/d1cc02930d
Abstract: The construction of the cyclopropyl quaternary carbon center can afford a series of 1,1-olefin bioisosteres. Here, we report tertiary cyclopropyl carbagermatranes, which can be easily obtained by the zinc-mediated decarboxylation of NHP esters. In addition,… read more here.
Keywords: tertiary cyclopropyl; cyclopropyl; carbagermatranes synthesis; cyclopropyl carbagermatranes ... See more keywords
Metal-Free Synthesis of Oxazinones and Their Reductive Ring Opening to Provide Cyclopropyl Carbinols
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DOI: 10.1055/s-0036-1588748
Abstract: General routes for the synthesis of 1,3-oxazin-4-ones are discussed, with particular attention paid to recent developments in the field. The syntheses of amine functionalised cyclopropyl carbinols via a hydride-mediated reduction of various 5-chloroethyl-1,3-oxazin-4-enones in moderate… read more here.
Keywords: free synthesis; cyclopropyl; oxazinones reductive; synthesis oxazinones ... See more keywords
Preparation of Chiral Enantioenriched Densely Substituted Cyclopropyl Azoles, Amines, and Ethers via Formal SN2′ Substitution of Bromocylopropanes
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27207069
Abstract: Enantiomerically enriched cyclopropyl ethers, amines, and cyclopropylazole derivatives possessing three stereogenic carbon atoms in a small cycle are obtained via the diastereoselective, formal nucleophilic substitution of chiral, non-racemic bromocyclopropanes. The key feature of this methodology… read more here.
Keywords: substitution; chiral enantioenriched; densely substituted; preparation chiral ... See more keywords