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1
Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c02759
Abstract: A sequence of nucleophilic ring opening of cyclopropyl ketones, N-quaternization, deprotonation, and [2,3]-sigmatropic rearrangement of ammonium ylides has been developed. This method enables efficient synthesis of bicyclic indolizidines bearing bridgehead aza-quaternary stereocenters from easily available…
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Keywords:
quaternary stereocenters;
rearrangement ammonium;
cyclopropyl ketones;
ammonium ylides ... See more keywords
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2
Published in 2023 at "Organic letters"
DOI: 10.1021/acs.orglett.3c00398
Abstract: By merging C-C and C-F bond cleavage, we developed a regioselective ring opening/gem-difluoroallylation of cyclopropyl ketones with α-trifluoromethylstyrenes, which proceeds under the catalysis of iron with the combination of manganese and TMSCl as the reducing…
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Keywords:
gem;
gem difluoroallylation;
cyclopropyl ketones;
opening gem ... See more keywords
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0
Published in 2020 at "Chemical communications"
DOI: 10.1039/d0cc05667g
Abstract: Utilizing the C4 reactive site of cyclopropyl ketones and a chiral N,N'-dioxide-scandium(iii) complex as a catalyst, a concise ring-opening/cyclization/thio-Michael cascade method was developed for the synthesis of chiral benzothiazole derivatives from a simple 2-aminothiophenol material.…
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Keywords:
lewis acid;
catalysed asymmetric;
cyclopropyl;
asymmetric cascade ... See more keywords
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0
Published in 2017 at "Synthesis"
DOI: 10.1055/s-0036-1588817
Abstract: We conducted detailed studies on CO-assisted reductive chemistry with cyclopropyl ketones as a special type of substrate. Multiple factors influencing the outcome of the reaction have been studied for both ruthenium and rhodium catalysis. An…
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Keywords:
bifunctional electrophiles;
aspects reductive;
reductive amination;
reaction ... See more keywords