Efficacy of Adjunctive D-Cycloserine to Intermittent Theta-Burst Stimulation for Major Depressive Disorder: A Randomized Clinical Trial.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA psychiatry"
DOI: 10.1001/jamapsychiatry.2022.3255
Abstract: Importance The antidepressant effects of transcranial magnetic stimulation protocols for major depressive disorder (MDD) are thought to depend on synaptic plasticity. The theta-burst stimulation (TBS) protocol synaptic plasticity is known to be N-methyl-D-aspartate (NMDA)-receptor dependent,… read more here.
Keywords: itbs plus; stimulation; cycloserine; clinical trial ... See more keywords
Efficacy of D‐cycloserine augmented brief intensive cognitive‐behavioural therapy for paediatric obsessive‐compulsive disorder: A randomised clinical trial
Sign Up to like & getrecommendations! Published in 2022 at "Depression and Anxiety"
DOI: 10.1002/da.23242
Abstract: To examine the efficacy of weight‐adjusted D‐cycloserine (DCS) (35 or 70 mg) relative to placebo augmentation of intensive exposure therapy for youth with obsessive‐compulsive disorder (OCD) in a double‐blind, randomised controlled trial, and examine whether antidepressant… read more here.
Keywords: therapy; efficacy; compulsive disorder; cycloserine ... See more keywords
Efficacy of adjunctive d-Cycloserine for the treatment of schizophrenia: a systematic review and meta-analysis of randomized controlled trials
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Neural Transmission"
DOI: 10.1007/s00702-020-02292-x
Abstract: d-Cycloserine is a partial agonist at the glycine site of the N-methyl-D-aspartate (NMDA) receptor. Results have been inconsistent in trials on the efficacy of d-Cycloserine in patients with schizophrenia. We examined the efficacy of d-Cycloserine… read more here.
Keywords: negative cognitive; randomized controlled; treatment; cycloserine ... See more keywords
Enhancing panic and smoking reduction treatment with D-Cycloserine: A pilot randomized clinical trial.
Sign Up to like & getrecommendations! Published in 2020 at "Drug and alcohol dependence"
DOI: 10.1016/j.drugalcdep.2020.107877
Abstract: In this placebo-controlled randomized clinical trial, we examined the efficacy of 250 mg d-cycloserine (DCS) for enhancing the effects of cognitive behavior therapy targeting anxiety sensitivity reduction in the context of smoking cessation treatment among… read more here.
Keywords: clinical trial; treatment; smoking; cycloserine ... See more keywords
d-Cycloserine facilitates extinction learning and enhances extinction-related brain activation
Sign Up to like & getrecommendations! Published in 2017 at "Neurobiology of Learning and Memory"
DOI: 10.1016/j.nlm.2017.08.003
Abstract: Extinction learning is modulated by N-methyl d-aspartate receptors (NMDAR) particularly in prefrontal and hippocampal brain regions. The use of of NMDA agonists in exposure therapy of anxiety disorders has been investigated in various patient groups.… read more here.
Keywords: context; extinction; cycloserine; extinction learning ... See more keywords
Bone Penetration of Cycloserine in Osteoarticular Tuberculosis Patients of China
Sign Up to like & getrecommendations! Published in 2022 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.02224-21
Abstract: The cycloserine concentrations in plasma and bone that were collected during operations on 28 osteoarticular tuberculosis (TB) patients treated daily with a 500-mg cycloserine-containing regimen were determined. The median concentrations in plasma and bone were… read more here.
Keywords: tuberculosis patients; osteoarticular tuberculosis; concentrations plasma; bone ... See more keywords
Investigating d-cycloserine as a potential pharmacological enhancer of an emotional bias learning procedure
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Psychopharmacology"
DOI: 10.1177/0269881118754679
Abstract: The partial N-methyl-D-aspartate receptor agonist d-cycloserine may enhance psychological therapies. However, its exact mechanism of action is still being investigated. Cognitive bias modification techniques allow isolation of cognitive processes and thus investigation of how they… read more here.
Keywords: bias modification; cycloserine; cognitive bias; bias ... See more keywords
D-cycloserine in Schizophrenia: New Strategies for Improving Clinical Outcomes by Enhancing Plasticity
Sign Up to like & getrecommendations! Published in 2017 at "Current Neuropharmacology"
DOI: 10.2174/1570159x14666160225154812
Abstract: Background Dysregulation of N-methyl D-aspartate (NMDA) receptor signaling is strongly implicated in schizophrenia. Based on the ketamine model of NMDA receptor hypoactivity, therapeutic approaches designed to maintain a sustained increase in agonist activity at the… read more here.
Keywords: nmda receptor; pharmacology; cycloserine schizophrenia; cycloserine ... See more keywords
Substrate Reduction Therapy for Krabbe Disease: Exploring the Repurposing of the Antibiotic D-Cycloserine
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Pediatrics"
DOI: 10.3389/fped.2021.807973
Abstract: Krabbe disease is a lysosomal storage disease that is caused by a deficiency in galactosylceramidase. Infantile onset disease is the most common presentation, which includes progressive neurological deterioration with corresponding demyelination, development of globoid cells,… read more here.
Keywords: therapy; cycloserine; twitcher mice; disease ... See more keywords