Cyclosporin A induces autophagy in cardiac fibroblasts through the NRP-2/WDFY-1 axis.
Sign Up to like & getrecommendations! Published in 2018 at "Biochimie"
DOI: 10.1016/j.biochi.2018.02.017
Abstract: Cyclosporin A (CsA) is an effective immunosuppressive agent, but its myocardial toxicity limits its widespread and long-term clinical application. In this study, CsA treatment led to damages in myocardial fiber structure, an increase in myocardial… read more here.
Keywords: fibrosis; cyclosporin; cardiac fibroblasts; nrp wdfy ... See more keywords
Structural Basis for Cyclosporin Isoform-Specific Inhibition of Cyclophilins from Toxoplasma gondii
Sign Up to like & getrecommendations! Published in 2023 at "ACS Infectious Diseases"
DOI: 10.1021/acsinfecdis.2c00566
Abstract: Cyclosporin (CsA) has antiparasite activity against the human pathogen Toxoplasma gondii. A possible mechanism of action involves CsA binding to T. gondii cyclophilins, although much remains to be understood. Herein, we characterize the functional and… read more here.
Keywords: inhibition; isoform; cyclosporin; structural basis ... See more keywords
Cyclosporin A-related cerebral venous sinus thrombosis
Sign Up to like & getrecommendations! Published in 2018 at "Medicine"
DOI: 10.1097/md.0000000000011642
Abstract: Rationale: Cerebral venous sinus thrombosis (CVST) is a complex life-threatening condition, and its etiology is not well understood. Although oral cyclosporin A is not a common cause of the symptoms related to CVST, there is… read more here.
Keywords: venous sinus; cyclosporin; sinus thrombosis; cerebral venous ... See more keywords
Relationship between allograft cyclosporin concentrations and Pâglycoprotein expression in the 1st month following renal transplantation
Sign Up to like & getrecommendations! Published in 2019 at "British Journal of Clinical Pharmacology"
DOI: 10.1111/bcp.13880
Abstract: The immunosuppressant cyclosporin is a P-glycoprotein (P-gp) substrate whose impaired function has been associated with an increased risk of cyclosporin-induced nephrotoxicity following renal transplantation. This study investigated the relationship between blood and allograft cyclosporin concentration,… read more here.
Keywords: cyclosporin; transplantation; allograft cyclosporin; expression ... See more keywords
Predictors and Outcomes of Dose Reduction of Methotrexate and Cyclosporin Graft-Versus-Host-Disease Prophylaxis Following Allogeneic Haematopoietic Cell Transplantation.
Sign Up to like & getrecommendations! Published in 2022 at "Internal medicine journal"
DOI: 10.1111/imj.15829
Abstract: BACKGROUND Concern regarding dose-related toxicities of methotrexate (MTX) and cyclosporin (CYA) GVHD prophylaxis occasionally lead to dose alterations post allogeneic haematopoietic cell transplant (alloHCT). AIM To clarify causes of MTX and CYA dose alteration and… read more here.
Keywords: allogeneic haematopoietic; haematopoietic cell; cyclosporin; alteration ... See more keywords
Binding of Different Cyclosporin Variants to Micelles Evidenced by NMR and MD Simulations
Sign Up to like & getrecommendations! Published in 2023 at "Membranes"
DOI: 10.3390/membranes13020196
Abstract: Peptides play a critical role in the life of organisms, performing completely different functions. The biological activity of some peptides, such as cyclosporins, can be determined by the degree of membrane permeability. Thus, it becomes… read more here.
Keywords: variants micelles; micelles evidenced; cyclosporin; cyclosporin variants ... See more keywords
New Nanoparticle Formulation for Cyclosporin A: In Vitro Assessment
Sign Up to like & getrecommendations! Published in 2021 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics13010091
Abstract: Cyclosporin A (CsA) is a molecule with well-known immunosuppressive properties. As it also acts on the opening of mitochondrial permeability transition pore (mPTP), CsA has been evaluated for ischemic heart diseases (IHD). However, its distribution… read more here.
Keywords: cyclosporin; sqcsa nps; nanoparticle formulation; new nanoparticle ... See more keywords
Lethal and Sublethal Toxicity Assessment of Cyclosporin C (a Fungal Toxin) against Plutella xylostella (L.)
Sign Up to like & getrecommendations! Published in 2022 at "Toxins"
DOI: 10.3390/toxins14080514
Abstract: Secondary metabolites/toxins produced by Purpeocillium lilacinum (Hypocreales; Phiocordycipitaceae), a well-known insect pathogen, can be used for the management of different insect pests. We report the lethal and sublethal effects of cyclosporin C (a toxin produced… read more here.
Keywords: cyclosporin; toxin; plutella xylostella; larval instars ... See more keywords