Efficacy and Safety of a Water-Free Topical Cyclosporine, 0.1%, Solution for the Treatment of Moderate to Severe Dry Eye Disease
Sign Up to like & getrecommendations! Published in 2023 at "JAMA Ophthalmology"
DOI: 10.1001/jamaophthalmol.2023.0709
Abstract: This randomized clinical trial investigates the effectiveness of a water-free cyclosporine eye drop, 0.1%, in the treatment of dry eye disease. read more here.
Keywords: dry eye; eye; water free; cyclosporine ... See more keywords
Phospholipid Cyclosporine Prodrugs Targeted at Inflammatory Bowel Disease (IBD) Treatment: Design, Synthesis, and in Vitro Validation
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DOI: 10.1002/cmdc.202000317
Abstract: Novel phospholipid (PL)‐cyclosporine conjugates were prepared and studied as potential prodrugs for inflammatory bowel disease (IBD). Our approach relies on phospholipase A2 (PLA2), which is overexpressed in the inflamed intestinal tissues, as the prodrug activator… read more here.
Keywords: phospholipid cyclosporine; bowel disease; inflammatory bowel; disease ibd ... See more keywords
Sirolimus‐ and cyclosporine‐loaded nanostructured lipid carriers: Development, characterization, and in vitro evaluation in T‐cell profiles of patients with a history of recurrent pregnancy loss
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DOI: 10.1002/rmb2.12509
Abstract: Abstract Purpose The authors developed nanostructured lipid carriers (NLCs) loaded with sirolimus (SRL) and cyclosporine (CsA) to improve their therapeutic efficacy in recurrent pregnancy loss (RPL) patients. Methods Mono‐delivery and co‐delivery of SRL and CsA… read more here.
Keywords: nanostructured lipid; nlcs nlcs; lipid carriers; recurrent pregnancy ... See more keywords
Cyclosporine therapy in cytokine storm due to coronavirus disease 2019 (COVID-19)
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DOI: 10.1007/s00296-020-04603-7
Abstract: There is no absolutely proven treatment for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The infection continues to spread rapidly worldwide and causes many people deaths. Patients with rheumatic disease can become easily and… read more here.
Keywords: infection; disease; rheumatology; sars cov ... See more keywords
Nephrotoxicity in children with frequently relapsing nephrotic syndrome receiving long-term cyclosporine treatment
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DOI: 10.1007/s00467-017-3641-4
Abstract: BackgroundSteroid-sparing drugs, such as cyclosporine, are recommended as treatment for children with frequently relapsing nephrotic syndrome (FRNS) and steroid-related toxicities. We recently reported a high rate of relapsing nephrotic syndrome 2 years after discontinuation of cyclosporine… read more here.
Keywords: long term; treatment; cyclosporine treatment; term cyclosporine ... See more keywords
Recent advances in cyclosporine drug delivery: challenges and opportunities
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DOI: 10.1007/s13346-019-00650-1
Abstract: Cyclosporine has been established as a gold standard for its immunosuppressant action. Apart from this, the molecule is boon in treating broad spectrum of diseases like rheumatoid arthritis, psoriasis, and dry eye syndrome. The broad… read more here.
Keywords: drug delivery; delivery; recent advances; advances cyclosporine ... See more keywords
Colon targeted bioadhesive pellets of curcumin and cyclosporine for improved management of inflammatory bowel disease
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DOI: 10.1007/s13346-020-00756-x
Abstract: The objective of the present work was to develop and optimize multiparticulate pH-dependent bioadhesive pellets of curcumin and cyclosporine for the management of intestinal bowel disease (IBD). The bioadhesive sustained release pellets were intended for… read more here.
Keywords: curcumin cyclosporine; management; drug; pellets curcumin ... See more keywords
Discovery of the anti-influenza A virus activity of SB216763 and cyclosporine A by mining infected cells and compound cellular signatures
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DOI: 10.1016/j.cclet.2021.09.017
Abstract: ABSTRACT In this study, SB216763 and cyclosporine A were identified as anti-influenza A virus (IAV) agents by transcriptome signature reversion (TSR) analysis through deep mining of the cellular transcriptome of human airway and lung cell… read more here.
Keywords: anti influenza; mining; sb216763 cyclosporine; influenza virus ... See more keywords
In vitro and in vivo evaluation of cyclosporine-graphene oxide laden hydrogel contact lenses.
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DOI: 10.1016/j.ijpharm.2021.121414
Abstract: Drug-eluting contact lens can substitute the multiple eye drop therapy. However, loading hydrophobic drug like cyclosporine in the contact lens is very challenging, due to low drug uptake (via soaking method); and alteration in the… read more here.
Keywords: contact lenses; cyclosporine; drug; laden contact ... See more keywords
Cyclosporine for treatment of acute generalized exanthematous pustulosis: a retrospective analysis.
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DOI: 10.1016/j.jaad.2020.02.069
Abstract: BACKGROUND Acute generalized exanthematous pustulosis (AGEP) is a severe cutaneous adverse reaction, typically to a medication, that is characterized by fever, neutrophilia, and a disseminated non-follicular pustular eruption. AGEP is typically self-resolving upon withdrawal of… read more here.
Keywords: time; cohort; acute generalized; exanthematous pustulosis ... See more keywords
A novel elastin‐like polypeptide drug carrier for cyclosporine A improves tear flow in a mouse model of Sjögren's syndrome
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Controlled Release"
DOI: 10.1016/j.jconrel.2018.10.026
Abstract: &NA; As a potent macrolide immunosuppressant, cyclosporine A (CsA) is used to treat multiple autoimmune diseases, including non‐autoimmune and autoimmune‐mediated dry eye disease, rheumatoid arthritis and psoriasis. Despite its potency, CsA has poor solubility, poor… read more here.
Keywords: gren syndrome; elastin like; model; like polypeptide ... See more keywords