The p38/CYLD Pathway is Involved in Necroptosis Induced by Oxygen-glucose Deprivation Combined with ZVAD in Primary Cortical Neurons
Sign Up to like & getrecommendations! Published in 2017 at "Neurochemical Research"
DOI: 10.1007/s11064-017-2244-6
Abstract: Recently, necroptosis, a form of programmed necrosis, has been widely studied. It has previously been shown that knockout of lysine 63 deubiquitinase CYLD significantly inhibits necroptosis in other cell lines, and serum response factor (SRF)… read more here.
Keywords: ogd zvad; necroptosis induced; glucose deprivation; necroptosis ... See more keywords
Loss of CYLD expression unleashes Wnt signaling in multiple myeloma and is associated with aggressive disease
Sign Up to like & getrecommendations! Published in 2017 at "Oncogene"
DOI: 10.1038/onc.2016.368
Abstract: Deletion or mutation of the gene encoding the deubiquitinating enzyme CYLD is a common genomic aberration in multiple myeloma (MM). However, the functional consequence of CYLD loss and the mechanism underlying its putative role as… read more here.
Keywords: myeloma; cyld; loss cyld; cyld expression ... See more keywords
Nuclear Translocation of RELB Is Increased in Diseased Human Liver and Promotes Ductular Reaction and Biliary Fibrosis in Mice.
Sign Up to like & getrecommendations! Published in 2019 at "Gastroenterology"
DOI: 10.1053/j.gastro.2018.11.018
Abstract: BACKGROUND & AIMS Cholangiocyte proliferation and ductular reaction contribute to the onset and progression of liver diseases. Little is known about the role of the transcription factor nuclear factor-κB (NF-κB) in this process. We investigated… read more here.
Keywords: cyld; liver; relb; lpc mice ... See more keywords
LncRNA growth arrest specific transcript 5 inhibits the growth of pituitary neuroendocrine tumors via miR-27a-5p/cylindromatosis axis
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2062086
Abstract: ABSTRACT The long noncoding RNA growth arrest-specific transcript 5 (GAS5) has been reported to function as a suppressor in many cancers. However, the role and mechanism of lncRNA GAS5 in pituitary neuroendocrine tumors (PitNETs) remain… read more here.
Keywords: growth; cyld; expression; mir 27a ... See more keywords
TRAF3 and NBR1 both influence the effect of the disease‐causing CYLD(Arg936X) mutation on NF‐κB activity
Sign Up to like & getrecommendations! Published in 2021 at "Experimental Dermatology"
DOI: 10.1111/exd.14365
Abstract: Recently described Hungarian and Anglo‐Saxon pedigrees that are affected by CYLD cutaneous syndrome (syn: Brooke‐Spiegler syndrome (BSS)) carry the same disease‐causing mutation (c.2806C>T, p.Arg936X) of the cylindromatosis (CYLD) gene but exhibit striking phenotypic differences. Using… read more here.
Keywords: traf3 nbr1; cyld arg936x; cyld; effect ... See more keywords
Shank3 regulates striatal synaptic abundance of Cyld, a deubiquitinase specific for Lys63‐linked polyubiquitin chains
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Neurochemistry"
DOI: 10.1111/jnc.14796
Abstract: The SH3 and multiple ankyrin repeat domains 3 (Shank3) proteins are core organizers of the postsynaptic density in neuronal excitatory synapses, and their defects cause various neurodevelopmental and neuropsychiatric disorders. Mechanistically, Shank3 directly and indirectly… read more here.
Keywords: synaptic abundance; lys63 linked; cyld; polyubiquitin chains ... See more keywords
The inhibitory effect of the deubiquitinase cylindromatosis (CYLD) on inflammatory responses in human gingival fibroblasts.
Sign Up to like & getrecommendations! Published in 2020 at "Oral diseases"
DOI: 10.1111/odi.13672
Abstract: OBJECTIVE Experiments were performed to evaluate CYLD expression in human gingival tissue samples and to examine the effects of CYLD on inflammatory responses in lipopolysaccharide (LPS)- or TNF-α-stimulated human gingival fibroblasts (HGFs). METHODS Immunohistochemistry for… read more here.
Keywords: inflammatory responses; tissue samples; cyld; cyld inflammatory ... See more keywords
CYLD Alterations in the Tumorigenesis and Progression of Human Papillomavirus–Associated Head and Neck Cancers
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Cancer Research"
DOI: 10.1158/1541-7786.mcr-20-0565
Abstract: Genetic alterations of CYLD lysine 63 deubiquitinase (CYLD), a tumor-suppressor gene encoding a deubiquitinase (DUB) enzyme, are associated with the formation of tumors in CYLD cutaneous syndrome. Genome sequencing efforts have revealed somatic CYLD alterations… read more here.
Keywords: cyld alterations; human papillomavirus; cyld; alterations tumorigenesis ... See more keywords
The deubiquitinase CYLD is a specific checkpoint of the STING antiviral signaling pathway
Sign Up to like & getrecommendations! Published in 2018 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1007435
Abstract: Stimulator of interferon genes (STING) is critical for cytosolic DNA-triggered innate immunity. STING is modified by several types of polyubiquitin chains. Here, we report that the deubiquitinase CYLD sustains STING signaling by stabilizing the STING… read more here.
Keywords: cyld; deubiquitinase cyld; signaling pathway; polyubiquitin chains ... See more keywords
CYLD Promotes Apoptosis of Nasopharyngeal Carcinoma Cells by Regulating NDRG1
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Management and Research"
DOI: 10.2147/cmar.s268216
Abstract: Purpose Nasopharyngeal carcinoma (NPC) is among the most common malignancies derived from the epithelium of the nasopharynx. To date, the regulatory networks involved in NPC have not been fully identified. Previous studies revealed multiple loss-of-function… read more here.
Keywords: cyld; cyld promotes; promotes apoptosis; apoptosis nasopharyngeal ... See more keywords
Rare CYLD Variants in Chinese Patients With Amyotrophic Lateral Sclerosis
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2021.740052
Abstract: Background: CYLD Lysine 63 Deubiquitinase gene (CYLD) was recently identified to be a novel causative gene for frontal temporal dementia (FTD)-amyotrophic lateral sclerosis (ALS). In the current study, we aimed to (1) systematically screen the… read more here.
Keywords: lateral sclerosis; cyld; burden analysis; rare variants ... See more keywords