Phenylboronic Acid Modification Augments the Lysosome Escape and Antitumor Efficacy of a Cylindrical Polymer Brush-Based Prodrug.
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DOI: 10.1021/jacs.1c09741
Abstract: Timely lysosome escape is of paramount importance for endocytosed nanomedicines to avoid premature degradation under the acidic and hydrolytic conditions in lysosomes. Herein, we report an exciting finding that phenylboronic acid (PBA) modification can greatly… read more here.
Keywords: based prodrug; phenylboronic acid; cylindrical polymer; escape ... See more keywords