Toxic Activation of an AAA+ Protease by the Antibacterial Drug Cyclomarin A.
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DOI: 10.1016/j.chembiol.2019.05.008
Abstract: ATP-driven bacterial AAA+ proteases have been recognized as drug targets. They possess an AAA+ protein (e.g., ClpC), which threads substrate proteins into an associated peptidase (e.g., ClpP). ATPase activity and substrate selection of AAA+ proteins… read more here.
Keywords: cyma; aaa protease; cyclomarin; clpc ... See more keywords