Pharmacokinetic profiles of a SARS‐COV‐2 neutralizing antibody BD‐604 in cynomolgus monkeys
Sign Up to like & getrecommendations! Published in 2021 at "Drug Testing and Analysis"
DOI: 10.1002/dta.3122
Abstract: Abstract Background Currently, severe acute respiratory syndrome coronavirus 2 (SARS‐COV‐2) has spread worldwide as a severe pandemic and effective therapeutic medications are urgently needed. As reported previously, BD‐604 is a fully human monoclonal antibody with… read more here.
Keywords: 604 cynomolgus; cynomolgus monkeys; pharmacokinetic profiles; antibody ... See more keywords
Functional and molecular characterization of UDP‐glucuronosyltransferase 2 family in cynomolgus macaques
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical Pharmacology"
DOI: 10.1016/j.bcp.2019.03.002
Abstract: Graphical abstract Figure. No caption available. &NA; UDP‐glucuronosyltransferases (UGTs) are essential enzymes metabolizing endogenous and exogenous chemicals. However, characteristics of UGTs have not been fully investigated in molecular levels of cynomolgus macaques, one of non‐human… read more here.
Keywords: molecular characterization; functional molecular; udp glucuronosyltransferase; cynomolgus macaques ... See more keywords
Age-related nomograms of serum anti-Mullerian hormone levels in female monkeys: Comparison of rhesus (Macaca mulatta) and cynomolgus (Macaca fascicularis) monkeys.
Sign Up to like & getrecommendations! Published in 2018 at "General and comparative endocrinology"
DOI: 10.1016/j.ygcen.2018.09.012
Abstract: AMH is regarded as a promising predictor for ovarian reserve in humans and non-human primate, and widely used in human medicine to predict ovarian response to gonadotropin, menopause and premature ovarian failure. However, large data… read more here.
Keywords: amh levels; rhesus; age; macaca ... See more keywords
High Expression of UGT1A1/1A6 in Monkey Small Intestine: Comparison of Protein Expression Levels of Cytochromes P450, UDP-Glucuronosyltransferases, and Transporters in Small Intestine of Cynomolgus Monkey and Human.
Sign Up to like & getrecommendations! Published in 2018 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.7b00772
Abstract: Cynomolgus monkeys have been widely used for the prediction of drug absorption in humans. The purpose of this study was to clarify the regional protein expression levels of cytochromes P450 (CYPs), UDP-glucuronosyltransferases (UGTs), and transporters… read more here.
Keywords: monkey; monkey human; small intestine; expression ... See more keywords
Quantitative Proteomic Analysis of Serum Reveals MST1 as a Potential Candidate Biomarker in Spontaneously Diabetic Cynomolgus Monkeys
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.2c05663
Abstract: The prevalence of type 2 diabetes (T2DM) is increasing globally, creating essential demands for T2DM animal models for the study of disease pathogenesis, prevention, and therapy. A non-human primate model such as cynomolgus monkeys can… read more here.
Keywords: serum; cynomolgus; cynomolgus monkeys; analysis ... See more keywords
Identification and characterization of the T cell receptor (TCR) repertoire of the cynomolgus macaque (Macaca Fascicularis)
Sign Up to like & getrecommendations! Published in 2022 at "BMC Genomics"
DOI: 10.1101/2022.03.30.486315
Abstract: Background Cynomolgus macaque ( Macaca fascicularis ) is an attractive animal model for the study of human disease and is extensively used in biomedical research. Cynomolgus macaques share behavioral, physiological, and genomic traits with humans… read more here.
Keywords: cynomolgus macaque; cynomolgus; tcr repertoire; macaque ... See more keywords
Population genetics of the ABO locus within the rhesus (Macaca mulatta) and cynomolgus (M. fascicularis) macaque hybrid zone
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Immunogenetics"
DOI: 10.1111/iji.12405
Abstract: Knowledge of the macaque ABO blood group system has been critical in the development of nonhuman primates (NHPs) as a translational model. Serving not only as a useful homologue of the disease‐linked ABO system in… read more here.
Keywords: rhesus; genetics; hybrid zone; blood ... See more keywords
Expression and metabolic activity of flavin‐containing monooxygenase 1 in cynomolgus macaque kidney
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Medical Primatology"
DOI: 10.1111/jmp.12385
Abstract: Flavin‐containing monooxygenase 1 (FMO1) largely remains to be characterized in cynomolgus macaque kidney. Immunoblotting showed expression of cynomolgus FMO1 in kidneys where activities of FMO1 (benzydamine N‐oxygenation) were detected. No sex differences were observed in… read more here.
Keywords: containing monooxygenase; flavin containing; cynomolgus macaque; cynomolgus ... See more keywords
Gene flow from rhesus (Macaca mulatta) to cynomolgus macaques (M. fascicularis) and effects of introgressive hybridization on reproduction in two biomedically relevant non‐human primate species
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Primatology"
DOI: 10.1111/jmp.12570
Abstract: We compared the reproductive patterns of wild Indochinese and Sundaic cynomolgus macaques (Mf) exhibiting different levels of genetic admixture with rhesus macaques (Mm). read more here.
Keywords: gene flow; cynomolgus; rhesus macaca; flow rhesus ... See more keywords
A Novel Fc-FGF21 With Improved Resistance to Proteolysis, Increased Affinity Toward &bgr;-Klotho, and Enhanced Efficacy in Mice and Cynomolgus Monkeys
Sign Up to like & getrecommendations! Published in 2017 at "Endocrinology"
DOI: 10.1210/en.2016-1917
Abstract: Fibroblast growth factor (FGF) 21 is a natural hormone that modulates glucose, lipid, and energy metabolism. Previously, we engineered an Fc fusion FGF21 variant with two mutations, Fc-FGF21(RG), to extend the half-life and reduce aggregation… read more here.
Keywords: fgf21 rge; affinity; rge; cynomolgus ... See more keywords
The utilization of advance telemetry to investigate critical physiological parameters including electroencephalography in cynomolgus macaques following aerosol challenge with eastern equine encephalitis virus
Sign Up to like & getrecommendations! Published in 2021 at "PLoS Neglected Tropical Diseases"
DOI: 10.1371/journal.pntd.0009424
Abstract: Most alphaviruses are mosquito-borne and can cause severe disease in humans and domesticated animals. In North America, eastern equine encephalitis virus (EEEV) is an important human pathogen with case fatality rates of 30–90%. Currently, there… read more here.
Keywords: equine encephalitis; encephalitis virus; challenge; eastern equine ... See more keywords